Gene description for Ubtf
Gene name upstream binding transcription factor, RNA polymerase I
Gene symbol Ubtf
Other names/aliases A930005G04Rik
NOR-90
Tcfubf
UBF
UBF-1
UBF1
Species Mus musculus
 Database cross references - Ubtf
ExoCarta ExoCarta_21429
Vesiclepedia VP_21429
Entrez Gene 21429
 Ubtf identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ubtf
Molecular Function
    RNA polymerase I core promoter sequence-specific DNA binding GO:0001164 IBA
    RNA polymerase I core promoter sequence-specific DNA binding GO:0001164 ISO
    RNA polymerase I cis-regulatory region sequence-specific DNA binding GO:0001165 ISO
    RNA polymerase I general transcription initiation factor activity GO:0001181 IBA
    RNA polymerase I general transcription initiation factor activity GO:0001181 ISO
    DNA binding GO:0003677 IEA
    chromatin binding GO:0003682 ISO
    chromatin binding GO:0003682 ISS
    protein binding GO:0005515 IPI
    scaffold protein binding GO:0097110 ISO
Biological Process
    transcription by RNA polymerase I GO:0006360 IBA
    transcription by RNA polymerase I GO:0006360 ISO
    transcription initiation at RNA polymerase I promoter GO:0006361 ISO
    transcription initiation at RNA polymerase I promoter GO:0006361 ISS
    transcription elongation by RNA polymerase I GO:0006362 IDA
    positive regulation of transcription by RNA polymerase I GO:0045943 IBA
    positive regulation of transcription by RNA polymerase I GO:0045943 IDA
    cellular response to leukemia inhibitory factor GO:1990830 IEP
Subcellular Localization
    fibrillar center GO:0001650 ISO
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleolus GO:0005730 IDA
    nucleolus GO:0005730 ISO
 Experiment description of studies that identified Ubtf in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ubtf
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Polr1b  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
2 Eif3l 223691
Affinity Capture-Western Mus musculus
3 Zbtb7b  
Affinity Capture-MS Mus musculus
4 Hdac1 433759
Biochemical Activity Mus musculus
Affinity Capture-Western Mus musculus
5 Atg16l1  
Affinity Capture-MS Mus musculus
6 Ctcf 13018
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
7 Polr1e  
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
8 Ctcfl  
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
9 CCNB1 891
Two-hybrid Homo sapiens
10 SMURF1 57154
Affinity Capture-Luminescence Homo sapiens
11 Rb1  
Co-fractionation Mus musculus
12 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
13 Ep300  
Biochemical Activity Mus musculus
14 Twist1  
Proximity Label-MS Mus musculus
15 Nanog  
Affinity Capture-MS Mus musculus
16 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Ubtf is involved
No pathways found





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