Gene description for FCN2
Gene name
ficolin (collagen/fibrinogen domain containing lectin) 2
Gene symbol
FCN2
Other names/aliases
EBP-37 FCNL P35 ficolin-2
Species
Homo sapiens
Database cross references - FCN2
ExoCarta
ExoCarta_2220
Vesiclepedia
VP_2220
Entrez Gene
2220
HGNC
3624
MIM
601624
UniProt
Q15485
FCN2 identified in sEVs derived from the following tissue/cell type
Plasma
19028452
Urine
19056867
Gene ontology annotations for FCN2
Experiment description of studies that identified FCN2 in sEVs
1
Experiment ID
44
MISEV standards
✔
IEM
Biophysical techniques
✘
Enriched markers
✘
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
19028452
Organism
Homo sapiens
Experiment description
Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Authors
"Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ"
Journal name
BBRC
Publication year
2009
Sample
Plasma
Sample name
Plasma
Isolation/purification methods
Filtration Size exclusion Sucrose density gradient
Flotation density
1.15-1.16 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry [LTQ] Western blotting Immunoelectron Microscopy
2
Experiment ID
63
MISEV standards
✘
Biophysical techniques
✔
AQP2
Enriched markers
✘
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
19056867
Organism
Homo sapiens
Experiment description
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors
"Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name
JASN
Publication year
2009
Sample
Urine
Sample name
Urine - Normal
Isolation/purification methods
Differential centrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry [LTQ] Western blotting
Protein-protein interactions for FCN2
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
MASP1
5648
Reconstituted Complex
Homo sapiens
2
FCN1
2219
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
3
MASP2
10747
Reconstituted Complex
Homo sapiens
View the network
image/svg+xml
Pathways in which FCN2 is involved