Gene description for Wdr26
Gene name WD repeat domain 26
Gene symbol Wdr26
Other names/aliases 1600024A01Rik
AA693241
AI447817
AU044014
C77982
Gid7
Species Mus musculus
 Database cross references - Wdr26
ExoCarta ExoCarta_226757
Vesiclepedia VP_226757
Entrez Gene 226757
UniProt Q8C6G8  
 Wdr26 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Wdr26
Molecular Function
    molecular_function GO:0003674 ND
Biological Process
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
Subcellular Localization
    ubiquitin ligase complex GO:0000151 ISO
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 IEA
    mitochondrion GO:0005739 ISO
    cytosol GO:0005829 ISO
    GID complex GO:0034657 IBA
 Experiment description of studies that identified Wdr26 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Wdr26
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Amfr  
Co-fractionation Mus musculus
2 Atg16l1  
Affinity Capture-MS Mus musculus
3 Wdr76  
Co-fractionation Mus musculus
4 Pde4dip  
Affinity Capture-MS Mus musculus
5 Cul4b  
Co-fractionation Mus musculus
6 Cul4a  
Co-fractionation Mus musculus
7 Ddb1 13194
Affinity Capture-MS Mus musculus
8 Brwd3  
Co-fractionation Mus musculus
9 GNB1 281201
Two-hybrid Bos taurus
View the network image/svg+xml



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