Experiment description of studies that identified CIC in sEVs

1 Experiment ID 237 MISEV standards ✔ Biophysical techniques ✔ Enriched markers ✔ Negative markers ✔ Particle analysis Identified molecule mRNA Identification method RNA Sequencing PubMed ID 26054723     Organism Homo sapiens Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N" Journal name Carcinogenesis Publication year 2015 Sample Hepatocytes Sample name MIHA Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient Flotation density 1.13-1.19 g/mL Molecules identified in the study Protein RNA Methods used in the study Western blotting Mass spectrometry RNA Sequencing

Protein-protein interactions for CIC

Protein Interactor ExoCarta ID Identification method PubMed Species 1 GTPBP3   Two-hybrid Homo sapiens 2 IRF4   Proximity Label-MS Homo sapiens 3 FEV   Proximity Label-MS Homo sapiens 4 NFIB   Proximity Label-MS Homo sapiens 5 LHX2   Proximity Label-MS Homo sapiens 6 NFYC 4802 Two-hybrid Homo sapiens Proximity Label-MS Homo sapiens 7 GATA2   Proximity Label-MS Homo sapiens 8 ACTC1 70 Proximity Label-MS Homo sapiens 9 PAX2   Proximity Label-MS Homo sapiens 10 EYA2   Proximity Label-MS Homo sapiens 11 Cep78   Affinity Capture-MS Mus musculus 12 SOX9   Proximity Label-MS Homo sapiens 13 SOX10   Proximity Label-MS Homo sapiens 14 ELF4 2000 Proximity Label-MS Homo sapiens 15 KLF8   Proximity Label-MS Homo sapiens 16 NUP35 129401 Proximity Label-MS Homo sapiens 17 SRC 6714 Biochemical Activity Homo sapiens Affinity Capture-Western Homo sapiens 18 YWHAG 7532 Affinity Capture-MS Homo sapiens 19 KLF15   Proximity Label-MS Homo sapiens 20 TEAD1   Proximity Label-MS Homo sapiens 21 YWHAH 7533 Affinity Capture-MS Homo sapiens 22 LHX4   Proximity Label-MS Homo sapiens 23 GCM1   Proximity Label-MS Homo sapiens 24 CSNK2B 1460 Two-hybrid Homo sapiens 25 SOX5 6660 Proximity Label-MS Homo sapiens 26 MAD2L1 4085 Affinity Capture-MS Homo sapiens 27 YWHAB 7529 Affinity Capture-MS Homo sapiens 28 HNF1A   Proximity Label-MS Homo sapiens 29 PRDM1   Proximity Label-MS Homo sapiens 30 HIST1H4A 8359 Affinity Capture-MS Homo sapiens 31 TLX3   Proximity Label-MS Homo sapiens 32 TBR1   Proximity Label-MS Homo sapiens 33 ZBTB18   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 34 NFIX 4784 Proximity Label-MS Homo sapiens 35 GOLGA2 2801 Proximity Label-MS Homo sapiens 36 CBX3 11335 Proximity Label-MS Homo sapiens 37 Ppp2ca 19052 Affinity Capture-MS Mus musculus 38 NFIA 4774 Proximity Label-MS Homo sapiens 39 GATA3   Proximity Label-MS Homo sapiens 40 NTRK1 4914 Affinity Capture-MS Homo sapiens 41 FOXK2   Affinity Capture-MS Homo sapiens 42 LHX3   Proximity Label-MS Homo sapiens 43 PLK1 5347 Two-hybrid Homo sapiens 44 PAX8   Proximity Label-MS Homo sapiens 45 T   Proximity Label-MS Homo sapiens 46 EN1   Proximity Label-MS Homo sapiens 47 KLF12   Proximity Label-MS Homo sapiens 48 CEBPA   Proximity Label-MS Homo sapiens 49 SOX17   Proximity Label-MS Homo sapiens 50 VSX1   Proximity Label-MS Homo sapiens 51 CD3EAP   Proximity Label-MS Homo sapiens 52 ATXN1 6310 Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Two-hybrid Homo sapiens 53 TLX2   Proximity Label-MS Homo sapiens 54 PICK1   Two-hybrid Homo sapiens 55 PAX6   Proximity Label-MS Homo sapiens 56 S100P 6286 Affinity Capture-MS Homo sapiens 57 LHX6   Proximity Label-MS Homo sapiens 58 SOX6   Proximity Label-MS Homo sapiens 59 ELK3   Proximity Label-MS Homo sapiens 60 SETD2   Two-hybrid Homo sapiens 61 NR3C1 2908 Proximity Label-MS Homo sapiens 62 FOXL1   Proximity Label-MS Homo sapiens 63 PYCR2 29920 Two-hybrid Homo sapiens 64 SOX15   Proximity Label-MS Homo sapiens 65 HNF4A   Proximity Label-MS Homo sapiens 66 FOS 2353 Proximity Label-MS Homo sapiens 67 RPA3 6119 Proximity Label-MS Homo sapiens 68 IRF8   Proximity Label-MS Homo sapiens 69 TRIM22 10346 Two-hybrid Homo sapiens 70 GABPB1   Two-hybrid Homo sapiens 71 FOXQ1   Proximity Label-MS Homo sapiens 72 MYB   Proximity Label-MS Homo sapiens 73 SOX2   Proximity Label-MS Homo sapiens 74 TLX1   Proximity Label-MS Homo sapiens 75 CENPJ 55835 Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens 76 KLF3   Proximity Label-MS Homo sapiens 77 PAX9   Proximity Label-MS Homo sapiens 78 KLF5   Proximity Label-MS Homo sapiens 79 PAX7   Proximity Label-MS Homo sapiens 80 SEC62 7095 Two-hybrid Homo sapiens 81 ERG   Proximity Label-MS Homo sapiens 82 ZNRD1   Two-hybrid Homo sapiens 83 HNF1B   Proximity Label-MS Homo sapiens 84 NFIC 4782 Proximity Label-MS Homo sapiens 85 AR 367 Proximity Label-MS Homo sapiens 86 SP7   Proximity Label-MS Homo sapiens View the network

Pathways in which CIC is involved

No pathways found