Gene description for SYT11
Gene name synaptotagmin XI
Gene symbol SYT11
Other names/aliases SYT12
sytXI
Species Homo sapiens
 Database cross references - SYT11
ExoCarta ExoCarta_23208
Vesiclepedia VP_23208
Entrez Gene 23208
HGNC 19239
MIM 608741
UniProt Q9BT88  
 SYT11 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SYT11
Molecular Function
    SNARE binding GO:0000149 IBA
    calcium ion binding GO:0005509 ISS
    protein binding GO:0005515 IPI
    calcium-dependent phospholipid binding GO:0005544 IBA
    calcium-dependent phospholipid binding GO:0005544 ISS
    translation initiation factor binding GO:0031369 IEA
    ubiquitin protein ligase binding GO:0031625 IPI
    identical protein binding GO:0042802 ISS
    beta-tubulin binding GO:0048487 IEA
    calcium ion sensor activity GO:0061891 IBA
Biological Process
    plasma membrane repair GO:0001778 ISS
    negative regulation of cytokine production GO:0001818 ISS
    vesicle fusion GO:0006906 IBA
    autophagy GO:0006914 IMP
    learning GO:0007612 ISS
    memory GO:0007613 ISS
    vesicle-mediated transport GO:0016192 IBA
    regulation of calcium ion-dependent exocytosis GO:0017158 IBA
    negative regulation of interleukin-6 production GO:0032715 ISS
    negative regulation of tumor necrosis factor production GO:0032720 ISS
    negative regulation of dopamine secretion GO:0033602 ISS
    negative regulation of endocytosis GO:0045806 ISS
    negative regulation of neurotransmitter secretion GO:0046929 TAS
    negative regulation of phagocytosis GO:0050765 ISS
    establishment of vesicle localization GO:0051650 ISS
    calcium-dependent activation of synaptic vesicle fusion GO:0099502 IBA
    regulation of synaptic vesicle endocytosis GO:1900242 IEA
    regulation of defense response to bacterium GO:1900424 IEA
    negative regulation of microglial cell activation GO:1903979 ISS
    regulation of phagosome maturation GO:1905162 IC
    positive regulation of protein localization to phagocytic vesicle GO:1905171 ISS
    calcium ion regulated lysosome exocytosis GO:1990927 ISS
Subcellular Localization
    phagocytic cup GO:0001891 IEA
    lysosome GO:0005764 ISS
    lysosomal membrane GO:0005765 IEA
    trans-Golgi network GO:0005802 ISS
    plasma membrane GO:0005886 IBA
    synaptic vesicle GO:0008021 ISS
    synaptic vesicle GO:0008021 ISS
    synaptic vesicle GO:0008021 TAS
    postsynaptic density GO:0014069 ISS
    axon GO:0030424 IBA
    axon GO:0030424 ISS
    dendrite GO:0030425 ISS
    clathrin-coated vesicle membrane GO:0030665 IEA
    vesicle GO:0031982 ISS
    early phagosome GO:0032009 ISS
    neuron projection GO:0043005 IDA
    dendritic spine GO:0043197 ISS
    perikaryon GO:0043204 IEA
    synapse GO:0045202 IBA
    phagocytic vesicle GO:0045335 ISS
    presynaptic active zone membrane GO:0048787 ISS
    recycling endosome GO:0055037 ISS
    recycling endosome membrane GO:0055038 IEA
    excitatory synapse GO:0060076 ISS
    inhibitory synapse GO:0060077 ISS
    exocytic vesicle GO:0070382 IBA
    dopaminergic synapse GO:0098691 IEA
    presynapse GO:0098793 ISS
 Experiment description of studies that identified SYT11 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SYT11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTPRF 5792
Affinity Capture-MS Homo sapiens
2 PDLIM7 9260
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 NTRK1 4914
Affinity Capture-MS Homo sapiens
4 AMDHD1  
Affinity Capture-MS Homo sapiens
5 TTC1 7265
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 APPBP2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 ATP13A2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
8 PARK2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
9 LRP10 26020
Affinity Capture-MS Homo sapiens
10 MCAM 4162
Proximity Label-MS Homo sapiens
11 GPR35  
Two-hybrid Homo sapiens
12 SGTB  
Two-hybrid Homo sapiens
13 TNFRSF10B 8795
Affinity Capture-MS Homo sapiens
14 PDLIM5 10611
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 ACVR1B 91
Affinity Capture-MS Homo sapiens
16 SLC20A1 6574
Affinity Capture-MS Homo sapiens
17 PTPRS 5802
Affinity Capture-MS Homo sapiens
18 JAK1 3716
Affinity Capture-MS Homo sapiens
19 DDR1 780
Affinity Capture-MS Homo sapiens
20 UBE2O 63893
Affinity Capture-MS Homo sapiens
21 ZBTB20 26137
Affinity Capture-MS Homo sapiens
22 SGTA 6449
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
23 ATP2B4 493
Affinity Capture-MS Homo sapiens
24 PRKAR1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here