Gene description for LRP10
Gene name low density lipoprotein receptor-related protein 10
Gene symbol LRP10
Other names/aliases LRP9
MST087
MSTP087
Species Homo sapiens
 Database cross references - LRP10
ExoCarta ExoCarta_26020
Vesiclepedia VP_26020
Entrez Gene 26020
HGNC 14553
MIM 609921
UniProt Q7Z4F1  
 LRP10 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Mesenchymal stem cells 36408942    
Prostate cancer cells 25844599    
 Gene ontology annotations for LRP10
Molecular Function
    low-density lipoprotein particle receptor activity GO:0005041 IBA
    protein binding GO:0005515 IPI
Biological Process
    lipid metabolic process GO:0006629 IEA
    lipid transport GO:0006869 IEA
    endocytosis GO:0006897 IEA
    inner ear development GO:0048839 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    clathrin-coated pit GO:0005905 IEA
    membrane GO:0016020 HDA
 Experiment description of studies that identified LRP10 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for LRP10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
2 RELT  
Affinity Capture-MS Homo sapiens
3 LRRIQ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 OR10H1  
Affinity Capture-MS Homo sapiens
5 LITAF 9516
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 RXFP1  
Affinity Capture-MS Homo sapiens
7 OR10H2  
Affinity Capture-MS Homo sapiens
8 WWP1 11059
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SLC39A4 55630
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 NRSN1  
Affinity Capture-MS Homo sapiens
11 IL20RB  
Affinity Capture-MS Homo sapiens
12 DLK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 CSNK1G2 1455
Affinity Capture-MS Homo sapiens
14 SMIM1 388588
Two-hybrid Homo sapiens
15 IFNGR1 3459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 GPR114  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 HEPACAM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 FAM26E  
Affinity Capture-MS Homo sapiens
19 TMEM179B 374395
Two-hybrid Homo sapiens
20 ADAM21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 TRDN 10345
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 HEATR3 55027
Affinity Capture-MS Homo sapiens
23 SLC20A1 6574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CTLA4  
Affinity Capture-MS Homo sapiens
25 TMEM130  
Affinity Capture-MS Homo sapiens
26 TMEM231 79583
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 GCNT4 51301
Affinity Capture-MS Homo sapiens
28 KLRC1  
Affinity Capture-MS Homo sapiens
29 GGA1 26088
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 C3orf52  
Affinity Capture-MS Homo sapiens
31 NOTO  
Two-hybrid Homo sapiens
32 HIATL1 84641
Two-hybrid Homo sapiens
33 RGS9BP  
Affinity Capture-MS Homo sapiens
34 ABHD14A  
Affinity Capture-MS Homo sapiens
35 EDAR  
Affinity Capture-MS Homo sapiens
36 GPRC5B 51704
Affinity Capture-MS Homo sapiens
37 TMEM59 9528
Affinity Capture-MS Homo sapiens
38 GPR17 2840
Affinity Capture-MS Homo sapiens
39 MANSC1 54682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 ST6GALNAC6 30815
Two-hybrid Homo sapiens
41 SCAP  
Affinity Capture-MS Homo sapiens
42 TSPAN3 10099
Affinity Capture-MS Homo sapiens
43 ZDHHC12  
Affinity Capture-MS Homo sapiens
44 PDCD1LG2 80380
Two-hybrid Homo sapiens
45 GORAB 92344
Two-hybrid Homo sapiens
46 C16orf58 64755
Affinity Capture-MS Homo sapiens
47 TMEM243  
Two-hybrid Homo sapiens
48 GPR182  
Affinity Capture-MS Homo sapiens
49 MRAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 GJB5  
Two-hybrid Homo sapiens
51 TMPRSS13  
Affinity Capture-MS Homo sapiens
52 TNFRSF10A 8797
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 SYT11 23208
Affinity Capture-MS Homo sapiens
54 PCDHA8  
Affinity Capture-MS Homo sapiens
55 P2RX4 5025
Affinity Capture-MS Homo sapiens
56 FAM189B  
Affinity Capture-MS Homo sapiens
57 CXCR4 7852
Affinity Capture-MS Homo sapiens
58 MARCH1  
Affinity Capture-MS Homo sapiens
59 ARRDC4  
Affinity Capture-MS Homo sapiens
60 NDFIP2 54602
Affinity Capture-MS Homo sapiens
61 SMIM5  
Affinity Capture-MS Homo sapiens
62 SLC14A2  
Two-hybrid Homo sapiens
63 TMPRSS3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 PTH2R  
Affinity Capture-MS Homo sapiens
65 Bmpr1a  
Affinity Capture-MS Mus musculus
66 GOLT1B 51026
Affinity Capture-MS Homo sapiens
67 CISD2 493856
Two-hybrid Homo sapiens
68 CASC4 113201
Two-hybrid Homo sapiens
69 FBXO6 26270
Affinity Capture-MS Homo sapiens
70 TMEM74  
Affinity Capture-MS Homo sapiens
71 C16orf92  
Two-hybrid Homo sapiens
72 FAM209A 200232
Two-hybrid Homo sapiens
73 KCNE3  
Affinity Capture-MS Homo sapiens
74 TMEM237 65062
Two-hybrid Homo sapiens
75 FBXO2 26232
Affinity Capture-MS Homo sapiens
76 SLC10A1  
Two-hybrid Homo sapiens
77 GGA2 23062
Proximity Label-MS Homo sapiens
78 TPCN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 ADORA2B  
Affinity Capture-MS Homo sapiens
80 TGFBR2 7048
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 SIDT2 51092
Affinity Capture-MS Homo sapiens
82 LDLRAD1  
Affinity Capture-MS Homo sapiens
83 FAM171B  
Affinity Capture-MS Homo sapiens
84 TNFRSF10D 8793
Affinity Capture-MS Homo sapiens
85 TSPAN17 26262
Affinity Capture-MS Homo sapiens
86 EBP  
Two-hybrid Homo sapiens
87 OR1M1  
Affinity Capture-MS Homo sapiens
88 OR2G6  
Affinity Capture-MS Homo sapiens
89 DDX58 23586
Affinity Capture-RNA Homo sapiens
90 CHRM3 1131
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 ALG6  
Affinity Capture-MS Homo sapiens
92 MRPS18B 28973
Two-hybrid Homo sapiens
93 SLC39A5 283375
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 LPAR2 9170
Affinity Capture-MS Homo sapiens
95 MARCH4  
Affinity Capture-MS Homo sapiens
96 IFNAR1  
Affinity Capture-MS Homo sapiens
97 SPINT2 10653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 MGST3 4259
Two-hybrid Homo sapiens
99 KCNE4  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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