Gene description for LITAF
Gene name lipopolysaccharide-induced TNF factor
Gene symbol LITAF
Other names/aliases PIG7
SIMPLE
TP53I7
Species Homo sapiens
 Database cross references - LITAF
ExoCarta ExoCarta_9516
Vesiclepedia VP_9516
Entrez Gene 9516
HGNC 16841
MIM 603795
UniProt Q99732  
 LITAF identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for LITAF
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IMP
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IBA
    zinc ion binding GO:0008270 IDA
    identical protein binding GO:0042802 IPI
    WW domain binding GO:0050699 IPI
Biological Process
    regulation of cytokine production GO:0001817 IBA
    regulation of macrophage cytokine production GO:0010935 IEA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 HMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    cellular response to lipopolysaccharide GO:0071222 IEA
    negative regulation of non-canonical NF-kappaB signal transduction GO:1901223 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    lysosomal membrane GO:0005765 IDA
    Golgi apparatus GO:0005794 IDA
    Golgi apparatus GO:0005794 IMP
    plasma membrane GO:0005886 IMP
    cytoplasmic side of plasma membrane GO:0009898 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    cytoplasmic side of early endosome membrane GO:0098559 IDA
    cytoplasmic side of late endosome membrane GO:0098560 IBA
    cytoplasmic side of late endosome membrane GO:0098560 IDA
    cytoplasmic side of lysosomal membrane GO:0098574 IBA
    cytoplasmic side of lysosomal membrane GO:0098574 IDA
 Experiment description of studies that identified LITAF in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LITAF
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 BAG3 9531
Affinity Capture-Luminescence Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
3 ARID5A  
Two-hybrid Homo sapiens
4 ATXN1 6310
Two-hybrid Homo sapiens
5 GGA3 23163
Two-hybrid Homo sapiens
6 RPS27A 6233
Two-hybrid Homo sapiens
7 TNIP1 10318
Two-hybrid Homo sapiens
8 CD320 51293
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SDCBP 6386
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 STAT6 6778
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
11 NEDD4 4734
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
12 REEP5 7905
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 HPCAL4  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 TTC33  
Affinity Capture-MS Homo sapiens
15 VSNL1 7447
Two-hybrid Homo sapiens
16 KIF14 9928
Affinity Capture-MS Homo sapiens
17 TAX1BP1 8887
Two-hybrid Homo sapiens
18 WWP1 11059
Affinity Capture-Western Homo sapiens
19 R3HDM1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 CACNB3  
Affinity Capture-Western Homo sapiens
21 WWOX 51741
Two-hybrid Homo sapiens
22 NCALD 83988
Two-hybrid Homo sapiens
23 HPCAL1 3241
Two-hybrid Homo sapiens
24 POGZ 23126
Two-hybrid Homo sapiens
25 UBQLN2 29978
Two-hybrid Homo sapiens
26 STAM2 10254
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
27 UBA52 7311
Two-hybrid Homo sapiens
28 KCNIP1  
Two-hybrid Homo sapiens
29 ARL8A 127829
Affinity Capture-MS Homo sapiens
30 TSG101 7251
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
31 PUM2 23369
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
33 ZIC1  
Two-hybrid Homo sapiens
34 RASSF3 283349
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 BMPR1A 657
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 RNF208  
Two-hybrid Homo sapiens
37 OPTN 10133
Two-hybrid Homo sapiens
38 LRP10 26020
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 CREB5 9586
Two-hybrid Homo sapiens
40 DAZAP2  
Two-hybrid Homo sapiens
41 WWP2 11060
Affinity Capture-Western Homo sapiens
42 FGFR2 2263
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 HECW2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 CYHR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 BCS1L 617
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 CACNA1C  
Affinity Capture-Western Homo sapiens
48 TAB2  
Affinity Capture-Western Homo sapiens
49 PUM1 9698
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 APOB 338
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 PTPRD 5789
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 KCNIP4 80333
Two-hybrid Homo sapiens
53 HIP1 3092
Two-hybrid Homo sapiens
54 HGS 9146
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
55 FGFR1 2260
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 TOM1 10043
Affinity Capture-Western Homo sapiens
57 CALCOCO2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
58 ACOX1 51
Affinity Capture-MS Homo sapiens
59 VENTX  
Two-hybrid Homo sapiens
60 UBQLN1 29979
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
61 ITCH 83737
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
62 NEDD4L 23327
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 REEP6  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
64 CARS 833
Affinity Capture-MS Homo sapiens
65 N4BP1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which LITAF is involved
No pathways found





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