Gene description for VSNL1
Gene name visinin-like 1
Gene symbol VSNL1
Other names/aliases HLP3
HPCAL3
HUVISL1
VILIP
VILIP-1
Species Homo sapiens
 Database cross references - VSNL1
ExoCarta ExoCarta_7447
Vesiclepedia VP_7447
Entrez Gene 7447
HGNC 12722
MIM 600817
UniProt P62760  
 VSNL1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for VSNL1
Molecular Function
    calcium ion binding GO:0005509 IBA
    protein binding GO:0005515 IPI
Biological Process
    regulation of signal transduction GO:0009966 IBA
    positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IEA
    positive regulation of exocytosis GO:0045921 IEA
    negative regulation of insulin secretion GO:0046676 IEA
Subcellular Localization
    cytosol GO:0005829 IEA
    membrane GO:0016020 IEA
 Experiment description of studies that identified VSNL1 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for VSNL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDCA8 55143
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 C1QTNF2  
Two-hybrid Homo sapiens
3 DNAAF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 TEX13B  
Two-hybrid Homo sapiens
5 LITAF 9516
Two-hybrid Homo sapiens
6 GFI1B  
Two-hybrid Homo sapiens
7 SPRED2 200734
Two-hybrid Homo sapiens
8 FAM131C  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 SRL 6345
Two-hybrid Homo sapiens
10 GPM6A 2823
Affinity Capture-MS Homo sapiens
11 NCALD 83988
Affinity Capture-MS Homo sapiens
12 ATXN1 6310
Two-hybrid Homo sapiens
13 EFNA1  
Affinity Capture-MS Homo sapiens
14 CDSN 1041
Two-hybrid Homo sapiens
15 ENDOD1 23052
Two-hybrid Homo sapiens
16 SPRY3  
Two-hybrid Homo sapiens
17 RAMP3  
Affinity Capture-MS Homo sapiens
18 DGUOK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 DTX2 113878
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
20 NUFIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 COL10A1  
Two-hybrid Homo sapiens
22 ARMC1 55156
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 TFF1 7031
Two-hybrid Homo sapiens
24 HAX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 SPRED1 161742
Two-hybrid Homo sapiens
26 FIBP 9158
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which VSNL1 is involved
No pathways found





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