Gene description for TFF1
Gene name trefoil factor 1
Gene symbol TFF1
Other names/aliases BCEI
D21S21
HP1.A
HPS2
pNR-2
pS2
Species Homo sapiens
 Database cross references - TFF1
ExoCarta ExoCarta_7031
Vesiclepedia VP_7031
Entrez Gene 7031
HGNC 11755
MIM 113710
UniProt P04155  
 TFF1 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TFF1
Molecular Function
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IEA
Biological Process
    carbohydrate metabolic process GO:0005975 TAS
    signal transduction GO:0007165 IEA
    cell population proliferation GO:0008283 IEA
    negative regulation of cell population proliferation GO:0008285 IEA
    response to iron ion GO:0010039 IEA
    cell differentiation GO:0030154 IEA
    maintenance of gastrointestinal epithelium GO:0030277 IBA
    response to immobilization stress GO:0035902 IEA
    response to peptide hormone GO:0043434 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified TFF1 in sEVs
1
Experiment ID 234
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TFF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBQLN4 56893
Two-hybrid Homo sapiens
2 ESR1  
Phenotypic Enhancement Homo sapiens
3 TFF1 7031
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
4 PRKCZ 5590
Phenotypic Enhancement Homo sapiens
5 PTRF 284119
Affinity Capture-Western Homo sapiens
6 NCOA3  
Phenotypic Enhancement Homo sapiens
7 SGTB  
Two-hybrid Homo sapiens
8 UBQLN1 29979
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 ZNF250  
Two-hybrid Homo sapiens
10 VSNL1 7447
Two-hybrid Homo sapiens
View the network image/svg+xml



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