Gene description for KCNIP4
Gene name Kv channel interacting protein 4
Gene symbol KCNIP4
Other names/aliases CALP
KCHIP4
Species Homo sapiens
 Database cross references - KCNIP4
ExoCarta ExoCarta_80333
Vesiclepedia VP_80333
Entrez Gene 80333
HGNC 30083
MIM 608182
UniProt Q6PIL6  
 KCNIP4 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for KCNIP4
Molecular Function
    potassium channel activity GO:0005267 IEA
    calcium ion binding GO:0005509 IBA
    calcium ion binding GO:0005509 IDA
    protein binding GO:0005515 IPI
    potassium channel regulator activity GO:0015459 IBA
    potassium channel regulator activity GO:0015459 ISS
Biological Process
    regulation of signal transduction GO:0009966 IBA
    potassium ion transmembrane transport GO:0071805 IEA
    protein localization to plasma membrane GO:0072659 ISS
    regulation of potassium ion transmembrane transport GO:1901379 IBA
    regulation of potassium ion transmembrane transport GO:1901379 ISS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    peroxisome GO:0005777 IDA
    endoplasmic reticulum GO:0005783 IEA
    cytosol GO:0005829 ISS
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    voltage-gated potassium channel complex GO:0008076 IBA
    voltage-gated potassium channel complex GO:0008076 ISS
    dendrite GO:0030425 IEA
    neuronal cell body GO:0043025 IEA
 Experiment description of studies that identified KCNIP4 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for KCNIP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 Kcnd2  
Affinity Capture-Western Rattus norvegicus
3 KCNIP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 TRH  
Two-hybrid Homo sapiens
5 IL17A  
Two-hybrid Homo sapiens
6 SCGB1D1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
8 MTX1 4580
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 KCNIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 LITAF 9516
Two-hybrid Homo sapiens
11 TFPI 7035
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 REEP2  
Affinity Capture-MS Homo sapiens
13 PSEN2 5664
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
14 GOLGA7 51125
Two-hybrid Homo sapiens
15 COL1A2 1278
Two-hybrid Homo sapiens
16 PRR4 11272
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 LACRT 90070
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 KLK4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 ZG16B 124220
Affinity Capture-MS Homo sapiens
20 ASPH 444
Two-hybrid Homo sapiens
21 MEOX2  
Two-hybrid Homo sapiens
22 PSEN1 5663
Two-hybrid Homo sapiens
23 ANKRD13A 88455
Affinity Capture-MS Homo sapiens
24 ECE2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KCNIP4 is involved
PathwayEvidenceSource
Cardiac conduction TAS Reactome
Muscle contraction TAS Reactome
Phase 1 - inactivation of fast Na+ channels TAS Reactome





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