Gene description for MTX1
Gene name metaxin 1
Gene symbol MTX1
Other names/aliases MTX
MTXN
Species Homo sapiens
 Database cross references - MTX1
ExoCarta ExoCarta_4580
Vesiclepedia VP_4580
Entrez Gene 4580
HGNC 7504
MIM 600605
UniProt Q13505  
 MTX1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for MTX1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    mitochondrion organization GO:0007005 IBA
    inner mitochondrial membrane organization GO:0007007 IC
    lactation GO:0007595 IEA
    protein insertion into mitochondrial outer membrane GO:0045040 NAS
Subcellular Localization
    SAM complex GO:0001401 HDA
    SAM complex GO:0001401 IBA
    SAM complex GO:0001401 IPI
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HTP
    mitochondrial outer membrane GO:0005741 NAS
    membrane GO:0016020 TAS
    MIB complex GO:0140275 HDA
 Experiment description of studies that identified MTX1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MTX1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC39A12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 MAP1LC3C  
Reconstituted Complex Homo sapiens
3 LYPD3 27076
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 DNAJC11 55735
Affinity Capture-MS Homo sapiens
5 A1BG 1
Reconstituted Complex Homo sapiens
6 NDUFS1 4719
Co-fractionation Homo sapiens
7 HCST  
Affinity Capture-MS Homo sapiens
8 NDUFB5 4711
Co-fractionation Homo sapiens
9 BSCL2  
Affinity Capture-MS Homo sapiens
10 HCRTR2  
Affinity Capture-MS Homo sapiens
11 FPR1  
Affinity Capture-MS Homo sapiens
12 FFAR1  
Affinity Capture-MS Homo sapiens
13 POTEF 728378
Co-fractionation Homo sapiens
14 MAP1LC3B 81631
Reconstituted Complex Homo sapiens
15 SLC18A2  
Affinity Capture-MS Homo sapiens
16 SLC15A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 COQ9  
Affinity Capture-MS Homo sapiens
18 GLMP 112770
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 DDOST 1650
Co-fractionation Homo sapiens
20 SURF1  
Proximity Label-MS Homo sapiens
21 RPN2 6185
Co-fractionation Homo sapiens
22 NDUFV1 4723
Co-fractionation Homo sapiens
23 TOMM40 10452
Reconstituted Complex Homo sapiens
24 SIGLEC12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 CLN8 2055
Two-hybrid Homo sapiens
26 PTH1R  
Affinity Capture-MS Homo sapiens
27 MAS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 NECAB1  
Co-fractionation Homo sapiens
29 BSG 682
Affinity Capture-MS Homo sapiens
30 SAMM50 25813
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
31 GCGR  
Affinity Capture-MS Homo sapiens
32 SLC5A6 8884
Affinity Capture-MS Homo sapiens
33 SLC39A9 55334
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 DIABLO 56616
Proximity Label-MS Homo sapiens
35 C12orf49  
Negative Genetic Homo sapiens
36 IL2RA  
Affinity Capture-MS Homo sapiens
37 C16orf58 64755
Affinity Capture-MS Homo sapiens
38 GABARAP 11337
Reconstituted Complex Homo sapiens
39 GPR182  
Affinity Capture-MS Homo sapiens
40 OPA1 4976
Proximity Label-MS Homo sapiens
41 UQCRC1 7384
Co-fractionation Homo sapiens
42 ACTB 60
Co-fractionation Homo sapiens
43 TMEM171  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 ADCK1  
Affinity Capture-MS Homo sapiens
45 CACNG4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 MLNR  
Affinity Capture-MS Homo sapiens
47 CISD3 284106
Affinity Capture-MS Homo sapiens
48 CISD1 55847
Co-fractionation Homo sapiens
49 HNRNPD 3184
Co-fractionation Homo sapiens
50 VIPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 EFNA4  
Affinity Capture-MS Homo sapiens
52 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 MINOS1  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
54 AIFM1 9131
Proximity Label-MS Homo sapiens
55 UQCRC2 7385
Co-fractionation Homo sapiens
56 PTH2R  
Affinity Capture-MS Homo sapiens
57 GPR12  
Affinity Capture-MS Homo sapiens
58 SLCO4C1 353189
Affinity Capture-MS Homo sapiens
59 HTR2C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 AQP3  
Affinity Capture-MS Homo sapiens
61 OPRL1 4987
Affinity Capture-MS Homo sapiens
62 GHITM 27069
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 SPTBN1 6711
Co-fractionation Homo sapiens
64 OCIAD1 54940
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
65 PHB2 11331
Proximity Label-MS Homo sapiens
66 MICB  
Affinity Capture-MS Homo sapiens
67 RPA3 6119
Proximity Label-MS Homo sapiens
68 APOOL 139322
Affinity Capture-MS Homo sapiens
69 GPR45  
Affinity Capture-MS Homo sapiens
70 C19orf70  
Affinity Capture-MS Homo sapiens
71 DNAJC10 54431
Co-fractionation Homo sapiens
72 GNRH1  
Affinity Capture-MS Homo sapiens
73 P2RY10  
Affinity Capture-MS Homo sapiens
74 KRAS 3845
Synthetic Lethality Homo sapiens
75 LMNA 4000
Proximity Label-MS Homo sapiens
76 AKAP1 8165
Proximity Label-MS Homo sapiens
77 SCCPDH 51097
Co-fractionation Homo sapiens
78 MAGEA8  
Affinity Capture-MS Homo sapiens
79 SLC2A12 154091
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 CLPP 8192
Proximity Label-MS Homo sapiens
81 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
82 FASN 2194
Positive Genetic Homo sapiens
83 SPTAN1 6709
Co-fractionation Homo sapiens
84 EDNRA 1909
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 TOMM22 56993
Co-fractionation Homo sapiens
86 MFSD4  
Affinity Capture-MS Homo sapiens
87 SLC26A6 65010
Affinity Capture-MS Homo sapiens
88 SQSTM1 8878
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
89 TMEM108  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 CD80 941
Affinity Capture-MS Homo sapiens
91 LPCAT2 54947
Affinity Capture-MS Homo sapiens
92 MAP1LC3A 84557
Reconstituted Complex Homo sapiens
93 PLXNA4 91584
Co-fractionation Homo sapiens
94 HLA-DPA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 POMK  
Affinity Capture-MS Homo sapiens
96 COX7A2 1347
Co-fractionation Homo sapiens
97 KCNIP4 80333
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 LPAR4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 TMBIM4  
Affinity Capture-MS Homo sapiens
100 CKAP4 10970
Co-fractionation Homo sapiens
101 TOMM5  
Co-fractionation Homo sapiens
102 HLA-C 3107
Affinity Capture-MS Homo sapiens
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