Gene description for SUN1
Gene name Sad1 and UNC84 domain containing 1
Gene symbol SUN1
Other names/aliases UNC84A
Species Homo sapiens
 Database cross references - SUN1
ExoCarta ExoCarta_23353
Vesiclepedia VP_23353
Entrez Gene 23353
HGNC 18587
MIM 607723
UniProt O94901  
 SUN1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SUN1
Molecular Function
    protein binding GO:0005515 IPI
    lamin binding GO:0005521 IEA
    identical protein binding GO:0042802 IPI
    protein-membrane adaptor activity GO:0043495 IBA
    cytoskeleton-nuclear membrane anchor activity GO:0140444 IDA
Biological Process
    ossification GO:0001503 IEA
    homologous chromosome pairing at meiosis GO:0007129 IEA
    spermatogenesis GO:0007283 IEA
    response to mechanical stimulus GO:0009612 IEA
    nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration GO:0021817 IEA
    centrosome localization GO:0051642 IEA
    meiotic attachment of telomere to nuclear envelope GO:0070197 IEA
    nuclear matrix anchoring at nuclear membrane GO:0090292 IDA
Subcellular Localization
    chromosome, telomeric region GO:0000781 IEA
    nuclear envelope GO:0005635 IDA
    nuclear envelope GO:0005635 IMP
    nuclear inner membrane GO:0005637 IEA
    cytoplasm GO:0005737 IEA
    nuclear membrane GO:0031965 IDA
    meiotic nuclear membrane microtubule tethering complex GO:0034993 IBA
    meiotic nuclear membrane microtubule tethering complex GO:0034993 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified SUN1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SUN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LRP3  
Affinity Capture-MS Homo sapiens
2 HSD17B11 51170
Proximity Label-MS Homo sapiens
3 CSGALNACT2 55454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 KLK15  
Affinity Capture-MS Homo sapiens
5 CNTNAP3  
Affinity Capture-MS Homo sapiens
6 METTL7A 25840
Proximity Label-MS Homo sapiens
7 LAMP3  
Proximity Label-MS Homo sapiens
8 GJA1 2697
Proximity Label-MS Homo sapiens
9 ZNF507  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ACKR2  
Affinity Capture-MS Homo sapiens
11 CTDNEP1 23399
Proximity Label-MS Homo sapiens
12 BSCL2  
Affinity Capture-MS Homo sapiens
13 MDFI  
Affinity Capture-MS Homo sapiens
14 SEC63 11231
Proximity Label-MS Homo sapiens
15 LAMP2 3920
Proximity Label-MS Homo sapiens
16 DNAJC25 548645
Proximity Label-MS Homo sapiens
17 CLEC12A  
Affinity Capture-MS Homo sapiens
18 TNFSF18 8995
Affinity Capture-MS Homo sapiens
19 CAPN6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TEX264 51368
Affinity Capture-MS Homo sapiens
21 B3GAT1  
Proximity Label-MS Homo sapiens
22 SCARA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 PRC1 9055
Affinity Capture-MS Homo sapiens
24 CLEC2B  
Affinity Capture-MS Homo sapiens
25 FBXO28  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 NCR3  
Affinity Capture-MS Homo sapiens
27 ST8SIA5  
Affinity Capture-MS Homo sapiens
28 SSR1 6745
Proximity Label-MS Homo sapiens
29 MARCH5  
Proximity Label-MS Homo sapiens
30 PIGH  
Affinity Capture-MS Homo sapiens
31 GJD3  
Proximity Label-MS Homo sapiens
32 C3orf52  
Affinity Capture-MS Homo sapiens
33 RPN2 6185
Proximity Label-MS Homo sapiens
34 DNAJC16  
Proximity Label-MS Homo sapiens
35 SLC25A46 91137
Proximity Label-MS Homo sapiens
36 RAB35 11021
Proximity Label-MS Homo sapiens
37 TMEM106A  
Affinity Capture-MS Homo sapiens
38 OBSL1 23363
Affinity Capture-MS Homo sapiens
39 MARCKS 4082
Proximity Label-MS Homo sapiens
40 KIF14 9928
Affinity Capture-MS Homo sapiens
41 LMAN1 3998
Proximity Label-MS Homo sapiens
42 NUP155 9631
Proximity Label-MS Homo sapiens
43 KIAA1715 80856
Proximity Label-MS Homo sapiens
44 APOO 79135
Proximity Label-MS Homo sapiens
45 LRRC59 55379
Proximity Label-MS Homo sapiens
46 HTR3C  
Affinity Capture-MS Homo sapiens
47 EMD 2010
Proximity Label-MS Homo sapiens
48 PARK2  
Affinity Capture-MS Homo sapiens
49 CYB5D2  
Affinity Capture-MS Homo sapiens
50 RAB4A 5867
Proximity Label-MS Homo sapiens
51 PDE3A  
Affinity Capture-MS Homo sapiens
52 MKRN2 23609
Affinity Capture-RNA Homo sapiens
53 SDF2L1 23753
Affinity Capture-MS Homo sapiens
54 LRRTM1 347730
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 SYNE1 23345
Affinity Capture-Western Homo sapiens
56 DNAJB9 4189
Affinity Capture-MS Homo sapiens
57 RPN1 6184
Proximity Label-MS Homo sapiens
58 DNAJC30  
Proximity Label-MS Homo sapiens
59 RHOT2 89941
Proximity Label-MS Homo sapiens
60 ELOVL5 60481
Proximity Label-MS Homo sapiens
61 SEC61B 10952
Proximity Label-MS Homo sapiens
62 TMPRSS13  
Affinity Capture-MS Homo sapiens
63 ZACN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 SYNE2 23224
Affinity Capture-Western Homo sapiens
65 REEP5 7905
Proximity Label-MS Homo sapiens
66 HTR3A  
Affinity Capture-MS Homo sapiens
67 KCNS3 3790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 FANCD2  
Affinity Capture-MS Homo sapiens
69 ECEL1  
Affinity Capture-MS Homo sapiens
70 DNAJB12 54788
Proximity Label-MS Homo sapiens
71 CALR3  
Proximity Label-MS Homo sapiens
72 LMNB1 4001
Proximity Label-MS Homo sapiens
73 TMEM9B 56674
Affinity Capture-MS Homo sapiens
74 GPR182  
Affinity Capture-MS Homo sapiens
75 CRELD1 78987
Affinity Capture-MS Homo sapiens
76 BCAP31 10134
Proximity Label-MS Homo sapiens
77 HSD3B7 80270
Proximity Label-MS Homo sapiens
78 FKBP8 23770
Proximity Label-MS Homo sapiens
79 NRM 11270
Affinity Capture-MS Homo sapiens
80 FBXO6 26270
Affinity Capture-MS Homo sapiens
81 DPEP1 1800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 EFTUD2 9343
Affinity Capture-MS Homo sapiens
83 Kif5b 16573
Affinity Capture-MS Mus musculus
84 ATP2A1 487
Proximity Label-MS Homo sapiens
85 FBXO2 26232
Affinity Capture-MS Homo sapiens
86 PTPN1 5770
Proximity Label-MS Homo sapiens
87 CMTM5  
Affinity Capture-MS Homo sapiens
88 RAB9A 9367
Proximity Label-MS Homo sapiens
89 GXYLT1 283464
Affinity Capture-MS Homo sapiens
90 MPPE1 65258
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 TYW5 129450
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 CYP2C9  
Proximity Label-MS Homo sapiens
93 LMNA 4000
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
94 PEX3 8504
Proximity Label-MS Homo sapiens
95 AKAP1 8165
Proximity Label-MS Homo sapiens
96 TRIP6 7205
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 HLA-G 3135
Affinity Capture-MS Homo sapiens
98 GP9 2815
Affinity Capture-MS Homo sapiens
99 PDIA4 9601
Proximity Label-MS Homo sapiens
100 TSPAN15 23555
Affinity Capture-MS Homo sapiens
101 KLC3  
Affinity Capture-MS Homo sapiens
102 PALD1 27143
Affinity Capture-MS Homo sapiens
103 ERGIC1 57222
Proximity Label-MS Homo sapiens
104 TAS1R3  
Affinity Capture-MS Homo sapiens
105 PDE6D 5147
Affinity Capture-MS Homo sapiens
106 SFTPC  
Affinity Capture-MS Homo sapiens
107 PXMP2  
Proximity Label-MS Homo sapiens
108 CLEC12B  
Affinity Capture-MS Homo sapiens
109 ERGIC2 51290
Proximity Label-MS Homo sapiens
110 HSPB8 26353
Affinity Capture-MS Homo sapiens
111 SEC62 7095
Proximity Label-MS Homo sapiens
112 ZNRF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 RAB7A 7879
Proximity Label-MS Homo sapiens
114 RAB11A 8766
Proximity Label-MS Homo sapiens
115 DNAJC1 64215
Proximity Label-MS Homo sapiens
116 RAB5C 5878
Proximity Label-MS Homo sapiens
117 PCDHB3  
Affinity Capture-MS Homo sapiens
118 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SUN1 is involved
PathwayEvidenceSource
Cell Cycle IEA Reactome
Meiosis IEA Reactome
Meiotic synapsis IEA Reactome
Reproduction IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here