Gene description for NRM
Gene name nurim (nuclear envelope membrane protein)
Gene symbol NRM
Other names/aliases NRM29
Species Homo sapiens
 Database cross references - NRM
ExoCarta ExoCarta_11270
Vesiclepedia VP_11270
Entrez Gene 11270
HGNC 8003
UniProt Q8IXM6  
 NRM identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for NRM
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    nuclear envelope GO:0005635 IDA
    nuclear inner membrane GO:0005637 IEA
    membrane GO:0016020 HDA
    nuclear membrane GO:0031965 IBA
    nuclear membrane GO:0031965 IDA
 Experiment description of studies that identified NRM in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NRM
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNASEH1 246243
Two-hybrid Homo sapiens
2 TMEM52B 120939
Two-hybrid Homo sapiens
3 KIR2DL3  
Two-hybrid Homo sapiens
4 GPX8 493869
Two-hybrid Homo sapiens
5 GPR151  
Two-hybrid Homo sapiens
6 SLC30A2  
Two-hybrid Homo sapiens
7 SLC10A6  
Two-hybrid Homo sapiens
8 GOLT1A  
Two-hybrid Homo sapiens
9 SSMEM1  
Two-hybrid Homo sapiens
10 ARL13B 200894
Two-hybrid Homo sapiens
11 FFAR2  
Two-hybrid Homo sapiens
12 TRIM59  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 ZG16B 124220
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 FRMD3  
Two-hybrid Homo sapiens
15 CLRN1  
Two-hybrid Homo sapiens
16 HS3ST2  
Affinity Capture-MS Homo sapiens
17 ERGIC3 51614
Two-hybrid Homo sapiens
18 HHLA2  
Two-hybrid Homo sapiens
19 PRMT6  
Affinity Capture-MS Homo sapiens
20 PEX12  
Two-hybrid Homo sapiens
21 CACNG6  
Affinity Capture-MS Homo sapiens
22 SYNE2 23224
Affinity Capture-MS Homo sapiens
23 AGR3 155465
Two-hybrid Homo sapiens
24 SLC10A2  
Two-hybrid Homo sapiens
25 FBXO6 26270
Affinity Capture-MS Homo sapiens
26 HDAC11  
Two-hybrid Homo sapiens
27 COPE 11316
Affinity Capture-MS Homo sapiens
28 MRM1  
Two-hybrid Homo sapiens
29 TNFSF18 8995
Affinity Capture-MS Homo sapiens
30 CREB3L1  
Two-hybrid Homo sapiens
31 PARP15  
Two-hybrid Homo sapiens
32 GORAB 92344
Two-hybrid Homo sapiens
33 FAM209A 200232
Two-hybrid Homo sapiens
34 FCER1G 2207
Two-hybrid Homo sapiens
35 GPR42  
Two-hybrid Homo sapiens
36 SUN1 23353
Affinity Capture-MS Homo sapiens
37 FAM134C 162427
Two-hybrid Homo sapiens
38 HSD17B13  
Two-hybrid Homo sapiens
39 STX1A 6804
Two-hybrid Homo sapiens
40 MGST3 4259
Two-hybrid Homo sapiens
41 CPLX4  
Two-hybrid Homo sapiens
42 ATP2B2 491
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 OPN1LW  
Two-hybrid Homo sapiens
44 ZMPSTE24 10269
Affinity Capture-MS Homo sapiens
45 ATP6V0B 533
Two-hybrid Homo sapiens
46 CNR2  
Two-hybrid Homo sapiens
47 TSPAN31 6302
Affinity Capture-MS Homo sapiens
48 C17orf62 79415
Two-hybrid Homo sapiens
49 MFF 56947
Two-hybrid Homo sapiens
50 TMUB1  
Affinity Capture-MS Homo sapiens
51 SUN2 25777
Two-hybrid Homo sapiens
52 TMX2 51075
Two-hybrid Homo sapiens
53 RMDN3 55177
Two-hybrid Homo sapiens
54 CRNN 49860
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NRM is involved
No pathways found





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