Gene description for FPGS
Gene name folylpolyglutamate synthase
Gene symbol FPGS
Other names/aliases -
Species Homo sapiens
 Database cross references - FPGS
ExoCarta ExoCarta_2356
Vesiclepedia VP_2356
Entrez Gene 2356
HGNC 3824
MIM 136510
UniProt Q05932  
 FPGS identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for FPGS
Molecular Function
    tetrahydrofolylpolyglutamate synthase activity GO:0004326 IBA
    tetrahydrofolylpolyglutamate synthase activity GO:0004326 IDA
    tetrahydrofolylpolyglutamate synthase activity GO:0004326 TAS
    ATP binding GO:0005524 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    liver development GO:0001889 IEA
    nucleobase-containing compound metabolic process GO:0006139 TAS
    glutamate metabolic process GO:0006536 IDA
    one-carbon metabolic process GO:0006730 IEA
    folic acid-containing compound metabolic process GO:0006760 IDA
    cell population proliferation GO:0008283 IMP
    animal organ regeneration GO:0031100 IEA
    folic acid metabolic process GO:0046655 TAS
    tetrahydrofolylpolyglutamate biosynthetic process GO:0046901 IBA
    tetrahydrofolylpolyglutamate biosynthetic process GO:0046901 IDA
    tetrahydrofolylpolyglutamate biosynthetic process GO:0046901 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IEA
    mitochondrial matrix GO:0005759 IDA
    mitochondrial matrix GO:0005759 TAS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified FPGS in sEVs
1
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FPGS
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RIT1 6016
Negative Genetic Homo sapiens
2 PALM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CGA  
Affinity Capture-MS Homo sapiens
4 GPR17 2840
Affinity Capture-MS Homo sapiens
5 TOR1AIP2 163590
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 LIPH 200879
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 PTH2R  
Affinity Capture-MS Homo sapiens
8 ACAA2 10449
Affinity Capture-MS Homo sapiens
9 THEM4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 LAMP2 3920
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 FAHD1 81889
Affinity Capture-MS Homo sapiens
12 AMACR 23600
Affinity Capture-MS Homo sapiens
13 ACACA 31
Negative Genetic Homo sapiens
14 DNAI2  
Affinity Capture-MS Homo sapiens
15 GPR182  
Affinity Capture-MS Homo sapiens
16 NIT1 4817
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 BICD2 23299
Proximity Label-MS Homo sapiens
18 HMGCL 3155
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 QRSL1  
Affinity Capture-MS Homo sapiens
20 KRAS 3845
Negative Genetic Homo sapiens
21 PTCD1 26024
Affinity Capture-MS Homo sapiens
22 AVPR2  
Affinity Capture-MS Homo sapiens
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