Gene description for Tsc2
Gene name	tuberous sclerosis 2
Gene symbol	Tsc2
Other names/aliases	Rc
Species	Rattus norvegicus
Database cross references - Tsc2
ExoCarta	ExoCarta_24855
Vesiclepedia	VP_24855
Entrez Gene	24855
UniProt	P49816
Tsc2 identified in sEVs derived from the following tissue/cell type
Hepatocytes	19367702

Gene ontology annotations for Tsc2

Molecular Function     GTPase activator activity GO:0005096 IBA     GTPase activator activity GO:0005096 IDA     GTPase activator activity GO:0005096 IEA     GTPase activator activity GO:0005096 ISO     GTPase activator activity GO:0005096 TAS     protein binding GO:0005515 IPI     phosphatase binding GO:0019902 IEA     phosphatase binding GO:0019902 ISO     phosphatase binding GO:0019902 ISS     small GTPase binding GO:0031267 IEA     small GTPase binding GO:0031267 ISO     protein homodimerization activity GO:0042803 IEA     protein homodimerization activity GO:0042803 ISO     protein-containing complex binding GO:0044877 IPI     Hsp90 protein binding GO:0051879 IEA     Hsp90 protein binding GO:0051879 ISO     14-3-3 protein binding GO:0071889 ISO Biological Process     response to hypoxia GO:0001666 ISO     neural tube closure GO:0001843 ISO     negative regulation of protein phosphorylation GO:0001933 IMP     transcription by RNA polymerase II GO:0006366 ISO     negative regulation of protein kinase activity GO:0006469 ISO     protein import into nucleus GO:0006606 ISO     heart development GO:0007507 ISO     protein localization GO:0008104 ISO     cell population proliferation GO:0008283 ISO     negative regulation of cell population proliferation GO:0008285 IMP     negative regulation of cell population proliferation GO:0008285 ISO     cellular response to starvation GO:0009267 IEA     cellular response to starvation GO:0009267 ISO     cellular response to starvation GO:0009267 ISS     positive regulation of autophagy GO:0010508 ISO     negative regulation of epithelial to mesenchymal transition GO:0010719 IMP     positive regulation of fibroblast migration GO:0010763 IMP     positive regulation of neuron projection development GO:0010976 IMP     positive regulation of macroautophagy GO:0016239 IEA     positive regulation of macroautophagy GO:0016239 ISO     positive regulation of macroautophagy GO:0016239 ISO     negative regulation of macroautophagy GO:0016242 IMP     establishment of cell polarity GO:0030010 IMP     cell projection organization GO:0030030 IGI     cell projection organization GO:0030030 IMP     regulation of endocytosis GO:0030100 ISO     negative regulation of Wnt signaling pathway GO:0030178 IBA     negative regulation of Wnt signaling pathway GO:0030178 IDA     negative regulation of B cell proliferation GO:0030889 ISO     negative regulation of TOR signaling GO:0032007 IBA     negative regulation of TOR signaling GO:0032007 IDA     negative regulation of TOR signaling GO:0032007 IEA     negative regulation of TOR signaling GO:0032007 ISO     negative regulation of TOR signaling GO:0032007 ISO     cellular response to insulin stimulus GO:0032869 ISO     protein localization to cell surface GO:0034394 IMP     social behavior GO:0035176 IMP     T cell proliferation GO:0042098 ISO     B cell proliferation GO:0042100 ISO     negative regulation of T cell proliferation GO:0042130 ISO     anoikis GO:0043276 IEA     anoikis GO:0043276 ISO     negative regulation of MAP kinase activity GO:0043407 IMP     protein transport into plasma membrane raft GO:0044861 ISO     positive regulation of cell adhesion GO:0045785 IMP     negative regulation of cell size GO:0045792 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     D-glucose import GO:0046323 ISO     regulation of insulin receptor signaling pathway GO:0046626 ISO     negative regulation of insulin receptor signaling pathway GO:0046627 IBA     positive regulation of insulin receptor signaling pathway GO:0046628 ISO     negative regulation of fibroblast proliferation GO:0048147 IDA     negative regulation of pinocytosis GO:0048550 IMP     negative regulation of epithelial cell proliferation GO:0050680 IDA     negative regulation of axonogenesis GO:0050771 IMP     positive chemotaxis GO:0050918 ISO     regulation of small GTPase mediated signal transduction GO:0051056 IEA     regulation of cell cycle GO:0051726 IBA     negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 IBA     negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 ISO     positive regulation of dendritic spine development GO:0060999 IMP     excitatory chemical synaptic transmission GO:0098976 ISO     inhibitory chemical synaptic transmission GO:0098977 ISO     regulation of postsynapse organization GO:0099175 IDA     regulation of postsynapse organization GO:0099175 IMP     negative regulation of TORC1 signaling GO:1904262 IEA     negative regulation of TORC1 signaling GO:1904262 ISO     negative regulation of TORC1 signaling GO:1904262 ISS     negative regulation of vascular endothelial cell proliferation GO:1905563 IMP Subcellular Localization     nucleus GO:0005634 IEA     nucleus GO:0005634 ISO     nucleus GO:0005634 ISO     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     lysosome GO:0005764 ISO     lysosomal membrane GO:0005765 IEA     lysosomal membrane GO:0005765 ISO     lysosomal membrane GO:0005765 ISS     Golgi apparatus GO:0005794 IEA     Golgi apparatus GO:0005794 ISO     Golgi apparatus GO:0005794 ISO     cytosol GO:0005829 ISO     cytosol GO:0005829 ISS     caveola GO:0005901 IDA     postsynaptic density GO:0014069 IEA     postsynaptic density GO:0014069 ISO     membrane GO:0016020 ISO     dendrite GO:0030425 IDA     growth cone GO:0030426 IDA     TSC1-TSC2 complex GO:0033596 IBA     TSC1-TSC2 complex GO:0033596 IEA     TSC1-TSC2 complex GO:0033596 ISO     TSC1-TSC2 complex GO:0033596 ISS     cell projection GO:0042995 IDA     neuronal cell body GO:0043025 IDA     synapse GO:0045202 ISO     perinuclear region of cytoplasm GO:0048471 IDA     perinuclear region of cytoplasm GO:0048471 IEA     perinuclear region of cytoplasm GO:0048471 ISO     glutamatergic synapse GO:0098978 IDA     glutamatergic synapse GO:0098978 IMP