Gene description for TXNDC8
Gene name thioredoxin domain containing 8 (spermatozoa)
Gene symbol TXNDC8
Other names/aliases SPTRX-3
TRX6
bA427L11.2
Species Homo sapiens
 Database cross references - TXNDC8
ExoCarta ExoCarta_255220
Vesiclepedia VP_255220
Entrez Gene 255220
HGNC 31454
UniProt Q6A555  
 TXNDC8 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for TXNDC8
Molecular Function
    protein-disulfide reductase activity GO:0015035 IDA
Biological Process
    spermatogenesis GO:0007283 IBA
    spermatogenesis GO:0007283 IEP
    cell differentiation GO:0030154 IEA
Subcellular Localization
    acrosomal vesicle GO:0001669 IEA
    cytoplasm GO:0005737 IDA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified TXNDC8 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for TXNDC8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ANKRD13A 88455
Affinity Capture-MS Homo sapiens
2 POTEKP 440915
Affinity Capture-MS Homo sapiens
3 PCBP4 57060
Affinity Capture-MS Homo sapiens
4 S100P 6286
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TXNDC8 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here