Gene description for LRIG1
Gene name leucine-rich repeats and immunoglobulin-like domains 1
Gene symbol LRIG1
Other names/aliases LIG-1
LIG1
Species Homo sapiens
 Database cross references - LRIG1
ExoCarta ExoCarta_26018
Vesiclepedia VP_26018
Entrez Gene 26018
HGNC 17360
MIM 608868
UniProt Q96JA1  
 LRIG1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LRIG1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    sensory perception of sound GO:0007605 IEA
    hair cycle process GO:0022405 IEA
    otolith morphogenesis GO:0032474 IEA
    innervation GO:0060384 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
    plasma membrane GO:0005886 TAS
    extracellular matrix GO:0031012 IBA
 Experiment description of studies that identified LRIG1 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LRIG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LRIG3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 UFSP2 55325
Affinity Capture-MS Homo sapiens
3 NBL1 4681
Two-hybrid Homo sapiens
4 SCRIB 23513
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ERBB2 2064
Affinity Capture-Western Homo sapiens
6 CLGN 1047
Affinity Capture-MS Homo sapiens
7 DEFA1 1667
Affinity Capture-MS Homo sapiens
8 RAB7A 7879
Proximity Label-MS Homo sapiens
9 TP53 7157
Affinity Capture-MS Homo sapiens
10 C1orf27 54953
Affinity Capture-MS Homo sapiens
11 HLA-E 3133
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 GAL3ST1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 ERBB4 2066
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
14 PON2 5445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 PDGFRA 5156
Affinity Capture-MS Homo sapiens
16 TUBB8 347688
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 MINOS1-NBL1  
Two-hybrid Homo sapiens
18 CANT1 124583
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 SPSB4  
Affinity Capture-MS Homo sapiens
20 RLN1  
Affinity Capture-MS Homo sapiens
21 IFNE  
Affinity Capture-MS Homo sapiens
22 EGFR 1956
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 CNPY3 10695
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 LYZL1  
Affinity Capture-MS Homo sapiens
26 ERBB3 2065
Affinity Capture-Western Homo sapiens
27 SPSB2  
Affinity Capture-MS Homo sapiens
28 MTFR1L 56181
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 INSL5  
Affinity Capture-MS Homo sapiens
30 CBL 867
Reconstituted Complex Homo sapiens
31 RAB4A 5867
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 CNPY4 245812
Affinity Capture-MS Homo sapiens
33 CLEC12B  
Affinity Capture-MS Homo sapiens
34 USP8 9101
Affinity Capture-Western Homo sapiens
35 IL15  
Affinity Capture-MS Homo sapiens
36 SCARA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 VCP 7415
Affinity Capture-MS Homo sapiens
38 FBXO2 26232
Affinity Capture-MS Homo sapiens
39 SCGB2A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 C1orf54  
Affinity Capture-MS Homo sapiens
41 TCTN2  
Affinity Capture-MS Homo sapiens
42 MET 4233
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
43 PTPRK 5796
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 GML  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 HGS 9146
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
46 KLRC1  
Affinity Capture-MS Homo sapiens
47 LRIG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 LRRC40 55631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 ST8SIA4 7903
Affinity Capture-MS Homo sapiens
50 CLRN2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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