Gene description for ZADH2
Gene name zinc binding alcohol dehydrogenase domain containing 2
Gene symbol ZADH2
Other names/aliases -
Species Homo sapiens
 Database cross references - ZADH2
ExoCarta ExoCarta_284273
Vesiclepedia VP_284273
Entrez Gene 284273
HGNC 28697
UniProt Q8N4Q0  
 ZADH2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ZADH2
Molecular Function
    zinc ion binding GO:0008270 IEA
    15-oxoprostaglandin 13-oxidase [NAD(P)+] activity GO:0047522 IBA
    15-oxoprostaglandin 13-oxidase [NAD(P)+] activity GO:0047522 ISS
Biological Process
    lipid metabolic process GO:0006629 IEA
    negative regulation of fat cell differentiation GO:0045599 ISS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    peroxisome GO:0005777 ISS
 Experiment description of studies that identified ZADH2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ZADH2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FGL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 CLPP 8192
Proximity Label-MS Homo sapiens
3 ECH1 1891
Affinity Capture-MS Homo sapiens
4 TRAPPC9 83696
Affinity Capture-MS Homo sapiens
5 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
6 C7orf43  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 DPP9 91039
Affinity Capture-MS Homo sapiens
8 MRPL21 219927
Affinity Capture-MS Homo sapiens
9 TRAPPC10 7109
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 MAD1L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 SLC9A3R2 9351
Affinity Capture-MS Homo sapiens
12 ATG101  
Affinity Capture-MS Homo sapiens
13 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
14 APP 351
Reconstituted Complex Homo sapiens
15 RBKS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CCNB1 891
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 TRAPPC4 51399
Affinity Capture-MS Homo sapiens
18 RPA3 6119
Proximity Label-MS Homo sapiens
19 Nedd4 25489
Reconstituted Complex Rattus norvegicus
20 JMY  
Affinity Capture-MS Homo sapiens
21 CYP24A1  
Affinity Capture-MS Homo sapiens
22 PEX5 5830
Affinity Capture-MS Homo sapiens
23 CKS2  
Affinity Capture-MS Homo sapiens
24 DBT 1629
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 TRAPPC5 126003
Affinity Capture-MS Homo sapiens
26 LNX1  
Reconstituted Complex Homo sapiens
27 NEDD4L 23327
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which ZADH2 is involved
No pathways found





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