Gene description for GLTSCR1
Gene name glioma tumor suppressor candidate region gene 1
Gene symbol GLTSCR1
Other names/aliases -
Species Homo sapiens
 Database cross references - GLTSCR1
ExoCarta ExoCarta_29998
Vesiclepedia VP_29998
Entrez Gene 29998
HGNC 4332
MIM 605690
UniProt Q9NZM4  
 GLTSCR1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for GLTSCR1
Molecular Function
    protein binding GO:0005515 IPI
    transcription regulator activator activity GO:0140537 IMP
Biological Process
    chromatin remodeling GO:0006338 NAS
    regulation of transcription by RNA polymerase II GO:0006357 NAS
    positive regulation of cell population proliferation GO:0008284 NAS
    negative regulation of cell differentiation GO:0045596 NAS
    positive regulation of DNA-templated transcription GO:0045893 IBA
    positive regulation of DNA-templated transcription GO:0045893 IMP
    positive regulation of stem cell population maintenance GO:1902459 NAS
Subcellular Localization
    chromatin GO:0000785 NAS
    nucleus GO:0005634 IMP
    SWI/SNF complex GO:0016514 IBA
    SWI/SNF complex GO:0016514 IDA
    GBAF complex GO:0140288 NAS
 Experiment description of studies that identified GLTSCR1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GLTSCR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3EAP  
Proximity Label-MS Homo sapiens
2 ARID1B 57492
Affinity Capture-MS Homo sapiens
3 BRD7  
Affinity Capture-MS Homo sapiens
4 KLF8  
Proximity Label-MS Homo sapiens
5 FASN 2194
Negative Genetic Homo sapiens
6 ASF1A 25842
Proximity Label-MS Homo sapiens
7 SMARCB1 6598
Affinity Capture-MS Homo sapiens
8 SMARCA2 6595
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ARID2  
Affinity Capture-MS Homo sapiens
10 FEV  
Proximity Label-MS Homo sapiens
11 NEIL3  
Affinity Capture-MS Homo sapiens
12 NFIX 4784
Proximity Label-MS Homo sapiens
13 SMARCD1 6602
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 GOLGA2 2801
Proximity Label-MS Homo sapiens
15 PPARG 5468
Proximity Label-MS Homo sapiens
16 SMARCC1 6599
Affinity Capture-MS Homo sapiens
17 TRIM66  
Affinity Capture-MS Homo sapiens
18 PBRM1 55193
Affinity Capture-MS Homo sapiens
19 ACTC1 70
Affinity Capture-MS Homo sapiens
20 SMARCE1 6605
Affinity Capture-MS Homo sapiens
21 BRD2  
Affinity Capture-MS Homo sapiens
22 SMARCD2 6603
Affinity Capture-MS Homo sapiens
23 SPATA1  
Affinity Capture-MS Homo sapiens
24 BCL7A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 SS18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 PAX6  
Proximity Label-MS Homo sapiens
27 DYNC1H1 1778
Affinity Capture-MS Homo sapiens
28 DPF1  
Affinity Capture-MS Homo sapiens
29 HNF4A  
Proximity Label-MS Homo sapiens
30 MYCN  
Affinity Capture-MS Homo sapiens
31 SMARCA4 6597
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 RNPS1 10921
Affinity Capture-MS Homo sapiens
33 SS18L2  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
34 BCL7C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 DPF2  
Affinity Capture-MS Homo sapiens
36 ACTL6A 86
Affinity Capture-MS Homo sapiens
37 ZCCHC10  
Affinity Capture-MS Homo sapiens
38 DPF3  
Affinity Capture-MS Homo sapiens
39 ERG  
Proximity Label-MS Homo sapiens
40 NFYC 4802
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
41 HNF1B  
Proximity Label-MS Homo sapiens
42 PARP1 142
Proximity Label-MS Homo sapiens
43 ARID1A 8289
Affinity Capture-MS Homo sapiens
44 STK11IP 114790
Affinity Capture-MS Homo sapiens
45 PHF10  
Affinity Capture-MS Homo sapiens
46 SMARCD3  
Affinity Capture-MS Homo sapiens
47 DDX58 23586
Affinity Capture-RNA Homo sapiens
48 SS18L1  
Affinity Capture-MS Homo sapiens
49 SP7  
Proximity Label-MS Homo sapiens
50 BRD9 65980
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 BRD3 8019
Affinity Capture-MS Homo sapiens
52 CEBPA  
Proximity Label-MS Homo sapiens
53 BRD4 23476
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
54 SMARCC2 6601
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GLTSCR1 is involved
No pathways found





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