Gene description for HSD17B2
Gene name hydroxysteroid (17-beta) dehydrogenase 2
Gene symbol HSD17B2
Other names/aliases EDH17B2
HSD17
SDR9C2
Species Homo sapiens
 Database cross references - HSD17B2
ExoCarta ExoCarta_3294
Vesiclepedia VP_3294
Entrez Gene 3294
HGNC 5211
MIM 109685
UniProt P37059  
 HSD17B2 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for HSD17B2
Molecular Function
    estradiol 17-beta-dehydrogenase [NAD(P)+] activity GO:0004303 IBA
    estradiol 17-beta-dehydrogenase [NAD(P)+] activity GO:0004303 IDA
    estradiol 17-beta-dehydrogenase [NAD(P)+] activity GO:0004303 TAS
    protein binding GO:0005515 IPI
    17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity GO:0047006 TAS
    testosterone dehydrogenase (NAD+) activity GO:0047035 IBA
    testosterone dehydrogenase (NAD+) activity GO:0047035 IDA
Biological Process
    in utero embryonic development GO:0001701 IEA
    placenta development GO:0001890 IEA
    estrogen biosynthetic process GO:0006703 IDA
    estrogen biosynthetic process GO:0006703 TAS
    steroid metabolic process GO:0008202 IBA
    androgen metabolic process GO:0008209 IDA
    response to retinoic acid GO:0032526 IDA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    intracellular membrane-bounded organelle GO:0043231 IBA
 Experiment description of studies that identified HSD17B2 in sEVs
1
Experiment ID 834
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for HSD17B2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARL6IP5 10550
Affinity Capture-MS Homo sapiens
2 REEP5 7905
Affinity Capture-MS Homo sapiens
3 ERGIC2 51290
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ERGIC3 51614
Affinity Capture-MS Homo sapiens
5 MBNL2 10150
Affinity Capture-MS Homo sapiens
6 INSR 3643
Affinity Capture-MS Homo sapiens
7 IFITM3 10410
Affinity Capture-MS Homo sapiens
8 REEP6  
Affinity Capture-MS Homo sapiens
9 TMEM109 79073
Affinity Capture-MS Homo sapiens
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