Gene description for NACA2
Gene name nascent polypeptide-associated complex alpha subunit 2
Gene symbol NACA2
Other names/aliases ANAC
NACAL
Species Homo sapiens
 Database cross references - NACA2
ExoCarta ExoCarta_342538
Vesiclepedia VP_342538
Entrez Gene 342538
HGNC 23290
MIM 609274
UniProt Q9H009  
 NACA2 identified in sEVs derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for NACA2
Molecular Function
    unfolded protein binding GO:0051082 IBA
Biological Process
    protein targeting to membrane GO:0006612 IBA
    protein transport GO:0015031 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    nascent polypeptide-associated complex GO:0005854 IEA
 Experiment description of studies that identified NACA2 in sEVs
1
Experiment ID 191
MISEV standards
Biophysical techniques
Alix|CD81|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NACA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDH2 1000
Co-fractionation Homo sapiens
2 CALU 813
Co-fractionation Homo sapiens
3 BTF3 689
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 P4HB 5034
Co-fractionation Homo sapiens
5 NACA 4666
Co-crystal Structure Homo sapiens
6 RPS13 6207
Co-fractionation Homo sapiens
7 CALR 811
Co-fractionation Homo sapiens
8 CDK2 1017
Affinity Capture-MS Homo sapiens
9 PTGES3 10728
Co-fractionation Homo sapiens
10 RPL32 6161
Co-fractionation Homo sapiens
11 TPD52 7163
Co-fractionation Homo sapiens
12 RPS25 6230
Co-fractionation Homo sapiens
13 RCN1 5954
Co-fractionation Homo sapiens
14 VCP 7415
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
15 RPL23 9349
Co-fractionation Homo sapiens
16 ISYNA1 51477
Co-fractionation Homo sapiens
17 PCNA 5111
Co-fractionation Homo sapiens
18 BCAP29 55973
Co-fractionation Homo sapiens
19 RPS21 6227
Co-fractionation Homo sapiens
20 BTF3L4 91408
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
21 TUFM 7284
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which NACA2 is involved
No pathways found





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