Gene description for IL15RA
Gene name interleukin 15 receptor, alpha
Gene symbol IL15RA
Other names/aliases CD215
Species Homo sapiens
 Database cross references - IL15RA
ExoCarta ExoCarta_3601
Vesiclepedia VP_3601
Entrez Gene 3601
HGNC 5978
MIM 601070
UniProt Q13261  
 IL15RA identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for IL15RA
Molecular Function
    cytokine receptor activity GO:0004896 TAS
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IPI
    interleukin-15 receptor activity GO:0042010 IBA
    interleukin-15 receptor activity GO:0042010 IDA
Biological Process
    natural killer cell differentiation GO:0001779 IEA
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 IEA
    negative regulation of neuron projection development GO:0010977 IEA
    response to nutrient levels GO:0031667 IEA
    positive regulation of natural killer cell differentiation GO:0032825 IEA
    interleukin-15-mediated signaling pathway GO:0035723 IBA
    interleukin-15-mediated signaling pathway GO:0035723 IMP
    positive regulation of phagocytosis GO:0050766 IMP
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    extracellular region GO:0005576 IEA
    endosome GO:0005768 TAS
    endoplasmic reticulum membrane GO:0005789 IEA
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 IDA
    cytoplasmic vesicle membrane GO:0030659 IEA
    nuclear membrane GO:0031965 IEA
 Experiment description of studies that identified IL15RA in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for IL15RA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDK2 1017
Two-hybrid Homo sapiens
2 POLR2F  
Affinity Capture-MS Homo sapiens
3 TRAF2 7186
Affinity Capture-Western Homo sapiens
4 RCVRN  
Two-hybrid Homo sapiens
5 CDK4 1019
Two-hybrid Homo sapiens
6 BCL10  
Two-hybrid Homo sapiens
7 PIAS4  
Two-hybrid Homo sapiens
8 CASK 8573
Two-hybrid Homo sapiens
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