Gene description for CASK
Gene name calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Gene symbol CASK
Other names/aliases CAGH39
CAMGUK
CMG
FGS4
LIN2
MICPCH
MRXSNA
TNRC8
Species Homo sapiens
 Database cross references - CASK
ExoCarta ExoCarta_8573
Vesiclepedia VP_8573
Entrez Gene 8573
HGNC 1497
MIM 300172
UniProt O14936  
 CASK identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 34887515    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocytes 26054723    
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for CASK
Molecular Function
    guanylate kinase activity GO:0004385 TAS
    protein serine/threonine kinase activity GO:0004674 IDA
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    signaling receptor binding GO:0005102 IBA
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IEA
    ATP binding GO:0005524 IEA
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    neurexin family protein binding GO:0042043 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    negative regulation of cell-matrix adhesion GO:0001953 IMP
    chromatin remodeling GO:0006338 IEA
    cell adhesion GO:0007155 TAS
    protein localization GO:0008104 IBA
    negative regulation of keratinocyte proliferation GO:0010839 IDA
    negative regulation of keratinocyte proliferation GO:0010839 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    GMP metabolic process GO:0046037 IEA
    GDP metabolic process GO:0046710 IEA
    regulation of neurotransmitter secretion GO:0046928 IBA
    establishment of localization in cell GO:0051649 IEA
    negative regulation of wound healing GO:0061045 IMP
    calcium ion import GO:0070509 IEA
    positive regulation of calcium ion import GO:0090280 IEA
    negative regulation of cellular response to growth factor stimulus GO:0090288 IMP
    regulation of synaptic vesicle exocytosis GO:2000300 IEA
Subcellular Localization
    basement membrane GO:0005604 IDA
    basement membrane GO:0005604 IDA
    nuclear lamina GO:0005652 IDA
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    cell-cell junction GO:0005911 IBA
    cell-cell junction GO:0005911 IDA
    focal adhesion GO:0005925 HDA
    actin cytoskeleton GO:0015629 TAS
    basolateral plasma membrane GO:0016323 IBA
    nuclear matrix GO:0016363 IDA
    vesicle GO:0031982 IEA
    presynaptic membrane GO:0042734 ISS
    ciliary membrane GO:0060170 ISS
    Schaffer collateral - CA1 synapse GO:0098685 IEA
 Experiment description of studies that identified CASK in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
10
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
14
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
15
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
16
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CASK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 MYBPHL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 F11R 50848
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
4 P2RX7 5027
Two-hybrid Homo sapiens
5 PARD3B 117583
Two-hybrid Homo sapiens
6 Pxdc1  
Affinity Capture-MS Mus musculus
7 FCHSD2  
Reconstituted Complex Homo sapiens
8 OCLN 100506658
Proximity Label-MS Homo sapiens
9 LIN7B  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
10 DLGAP2  
Affinity Capture-MS Homo sapiens
11 GJA1 2697
Proximity Label-MS Homo sapiens
12 SRPK2 6733
Biochemical Activity Homo sapiens
13 FMR1 2332
Two-hybrid Homo sapiens
14 RPA2 6118
Two-hybrid Homo sapiens
15 ID1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
16 FBXL19  
Affinity Capture-MS Homo sapiens
17 C9orf78 51759
Affinity Capture-MS Homo sapiens
18 BNIP3L  
Two-hybrid Homo sapiens
19 PRPF3  
Two-hybrid Homo sapiens
20 WNT7B 7477
Two-hybrid Homo sapiens
21 ZNF414  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SLC16A6 9120
Affinity Capture-MS Homo sapiens
23 APEX1 328
Affinity Capture-RNA Homo sapiens
24 PKP2 5318
Two-hybrid Homo sapiens
25 MARK2 2011
Two-hybrid Homo sapiens
26 C20orf85  
Two-hybrid Homo sapiens
27 EPB41 2035
Reconstituted Complex Homo sapiens
28 ABLIM1 3983
Affinity Capture-MS Homo sapiens
29 KCNJ4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
30 PRC1 9055
Two-hybrid Homo sapiens
31 C8orf82  
Proximity Label-MS Homo sapiens
32 HGS 9146
Reconstituted Complex Homo sapiens
33 CNTNAP2  
Reconstituted Complex Homo sapiens
34 C11orf52 91894
Proximity Label-MS Homo sapiens
35 SRP14 6727
Affinity Capture-MS Homo sapiens
36 MARS 4141
Two-hybrid Homo sapiens
37 MLLT6  
Two-hybrid Homo sapiens
38 KLC4 89953
Two-hybrid Homo sapiens
39 GTSE1 51512
Two-hybrid Homo sapiens
40 MECP2 4204
Affinity Capture-MS Homo sapiens
41 RAB35 11021
Proximity Label-MS Homo sapiens
42 EBAG9 9166
Proximity Label-MS Homo sapiens
43 KCNA4  
Affinity Capture-MS Homo sapiens
44 RBM14 10432
Two-hybrid Homo sapiens
45 UIMC1  
Affinity Capture-MS Homo sapiens
46 LAMTOR1 55004
Proximity Label-MS Homo sapiens
47 MED1 5469
Two-hybrid Homo sapiens
48 PPM1B 5495
Co-fractionation Homo sapiens
49 TRIM26 7726
Affinity Capture-MS Homo sapiens
50 ARHGEF26 26084
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 PARK2  
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
52 PTGS2 5743
Two-hybrid Homo sapiens
53 PLK2  
Two-hybrid Homo sapiens
54 DLGAP4 22839
Affinity Capture-MS Homo sapiens
55 TBR1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
56 SMEK1 55671
Two-hybrid Homo sapiens
57 LYN 4067
Proximity Label-MS Homo sapiens
58 MAPRE1 22919
Two-hybrid Homo sapiens
59 MCAM 4162
Proximity Label-MS Homo sapiens
60 DNAJC5 80331
Proximity Label-MS Homo sapiens
61 CNTNAP4 85445
Reconstituted Complex Homo sapiens
62 MKRN2 23609
Affinity Capture-RNA Homo sapiens
63 YWHAE 7531
Two-hybrid Homo sapiens
64 NDOR1  
Affinity Capture-MS Homo sapiens
65 DTNB 1838
Affinity Capture-MS Homo sapiens
66 NTRK1 4914
Affinity Capture-MS Homo sapiens
67 LIN7C 55327
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 MLX  
Two-hybrid Homo sapiens
69 SPATA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 EEF2 1938
Affinity Capture-MS Homo sapiens
71 KLHL2 11275
Affinity Capture-MS Homo sapiens
72 DDX54 79039
Two-hybrid Homo sapiens
73 RBM5  
Two-hybrid Homo sapiens
74 F11r  
Affinity Capture-Western Mus musculus
75 APBA1  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
76 ATP2B4 493
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
77 EPB41L5 57669
Affinity Capture-MS Homo sapiens
78 MYCL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 RBM10  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
80 PCBP2 5094
Two-hybrid Homo sapiens
81 ELL2 22936
Two-hybrid Homo sapiens
82 RBBP6 5930
Two-hybrid Homo sapiens
83 SF3B2 10992
Two-hybrid Homo sapiens
84 Lin7c 22343
Affinity Capture-MS Mus musculus
85 IL15RA 3601
Two-hybrid Homo sapiens
86 HADHA 3030
Affinity Capture-MS Homo sapiens
87 SDC1 6382
Reconstituted Complex Homo sapiens
88 TSPYL2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
89 EPB41L4A 64097
Proximity Label-MS Homo sapiens
90 LAMP1 3916
Proximity Label-MS Homo sapiens
91 DLG1 1739
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
92 ARF6 382
Proximity Label-MS Homo sapiens
93 DLG4  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
94 EFCAB11  
Affinity Capture-MS Homo sapiens
95 SDC2 6383
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
96 KIF26B  
Affinity Capture-MS Homo sapiens
97 LIN7A 8825
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
98 PRKCI 5584
Two-hybrid Homo sapiens
99 DEFB136  
Affinity Capture-MS Homo sapiens
100 CUL9  
Affinity Capture-MS Homo sapiens
101 SLAIN2  
Two-hybrid Homo sapiens
102 MYC  
Affinity Capture-MS Homo sapiens
103 RPA3 6119
Proximity Label-MS Homo sapiens
104 Caskin1  
Two-hybrid Rattus norvegicus
105 TRIM22 10346
Two-hybrid Homo sapiens
106 PTPDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 RHOB 388
Proximity Label-MS Homo sapiens
108 PCM1 5108
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
109 FLOT1 10211
Proximity Label-MS Homo sapiens
110 FAM133A 286499
Affinity Capture-MS Homo sapiens
111 RPH3A 22895
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
112 TULP4 56995
Affinity Capture-MS Homo sapiens
113 GCNT3 9245
Two-hybrid Homo sapiens
114 PRKD2 25865
Two-hybrid Homo sapiens
115 EIF1AD 84285
Affinity Capture-MS Homo sapiens
116 SURF6  
Affinity Capture-MS Homo sapiens
117 KIF2A 3796
Two-hybrid Homo sapiens
118 IL18 3606
Two-hybrid Homo sapiens
119 ZNF785  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 DUSP10 11221
Affinity Capture-MS Homo sapiens
121 FOXRED2  
Affinity Capture-MS Homo sapiens
122 PARD6G 84552
Two-hybrid Homo sapiens
123 DUSP3 1845
Two-hybrid Homo sapiens
124 MAPRE2 10982
Two-hybrid Homo sapiens
125 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
126 DDX58 23586
Affinity Capture-RNA Homo sapiens
127 NPPB  
Affinity Capture-MS Homo sapiens
128 NEDD1 121441
Affinity Capture-MS Homo sapiens
129 CDK9 1025
Two-hybrid Homo sapiens
130 NDEL1 81565
Two-hybrid Homo sapiens
131 EPHA2 1969
Proximity Label-MS Homo sapiens
132 KRAS 3845
Proximity Label-MS Homo sapiens
133 SH2D4A 63898
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
134 SNTB2 6645
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 CAV1 857
Proximity Label-MS Homo sapiens
136 KCNJ12 3768
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
137 AKAP9 10142
Two-hybrid Homo sapiens
138 ARIH1 25820
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here