Gene description for P2RX7
Gene name	purinergic receptor P2X, ligand gated ion channel, 7
Gene symbol	P2RX7
Other names/aliases	P2X7
Species	Homo sapiens
Database cross references - P2RX7
ExoCarta	ExoCarta_5027
Vesiclepedia	VP_5027
Entrez Gene	5027
HGNC	8537
MIM	602566
UniProt	Q99572
P2RX7 identified in sEVs derived from the following tissue/cell type
Melanoma cells	34789738
Melanoma cells	34789738

Gene ontology annotations for P2RX7

Molecular Function     lipopolysaccharide binding GO:0001530 ISS     purinergic nucleotide receptor activity GO:0001614 IDA     extracellularly ATP-gated monoatomic cation channel activity GO:0004931 IBA     extracellularly ATP-gated monoatomic cation channel activity GO:0004931 IDA     signaling receptor binding GO:0005102 ISS     protein binding GO:0005515 IPI     ATP binding GO:0005524 IC     identical protein binding GO:0042802 ISS Biological Process     MAPK cascade GO:0000165 IEA     cell morphogenesis GO:0000902 IEA     phagolysosome assembly GO:0001845 IEA     T cell mediated cytotoxicity GO:0001913 IEA     positive regulation of T cell mediated cytotoxicity GO:0001916 IEA     regulation of sodium ion transport GO:0002028 ISS     response to ischemia GO:0002931 NAS     membrane protein ectodomain proteolysis GO:0006509 IEA     phospholipid transfer to membrane GO:0006649 IEA     vesicle budding from membrane GO:0006900 IEA     inflammatory response GO:0006954 IEA     mitochondrion organization GO:0007005 IEA     cell surface receptor signaling pathway GO:0007166 IBA     cell surface receptor signaling pathway GO:0007166 ISS     protein secretion GO:0009306 IEA     response to xenobiotic stimulus GO:0009410 IEA     response to mechanical stimulus GO:0009612 IEA     response to zinc ion GO:0010043 IEA     positive regulation of calcium ion transport into cytosol GO:0010524 IDA     positive regulation of gene expression GO:0010628 IMP     glutamate secretion GO:0014047 IEA     positive regulation of glutamate secretion GO:0014049 IEA     gamma-aminobutyric acid secretion GO:0014051 IEA     positive regulation of gamma-aminobutyric acid secretion GO:0014054 IEA     synaptic vesicle exocytosis GO:0016079 IEA     protein processing GO:0016485 IEA     plasma membrane phospholipid scrambling GO:0017121 IDA     sensory perception of pain GO:0019233 ISS     calcium-mediated signaling GO:0019722 TAS     protein catabolic process GO:0030163 IEA     positive regulation of bone mineralization GO:0030501 ISS     bleb assembly GO:0032060 IDA     bleb assembly GO:0032060 ISS     positive regulation of prostaglandin secretion GO:0032308 IEA     prostaglandin secretion GO:0032310 IEA     response to lipopolysaccharide GO:0032496 IEA     positive regulation of interleukin-1 alpha production GO:0032730 IEA     positive regulation of interleukin-1 beta production GO:0032731 IDA     positive regulation of interleukin-6 production GO:0032755 IEA     collagen metabolic process GO:0032963 IEA     response to ATP GO:0033198 IDA     response to fluid shear stress GO:0034405 IEA     positive regulation of monoatomic ion transmembrane transport GO:0034767 IMP     purinergic nucleotide receptor signaling pathway GO:0035590 IMP     purinergic nucleotide receptor signaling pathway GO:0035590 TAS     T cell proliferation GO:0042098 IEA     T cell homeostasis GO:0043029 IEA     NAD transport GO:0043132 IEA     negative regulation of MAPK cascade GO:0043409 ISS     positive regulation of MAPK cascade GO:0043410 IEA     negative regulation of bone resorption GO:0045779 ISS     negative regulation of cell volume GO:0045794 IMP     positive regulation of glycolytic process GO:0045821 IMP     ceramide biosynthetic process GO:0046513 IEA     pore complex assembly GO:0046931 IDA     pore complex assembly GO:0046931 IMP     skeletal system morphogenesis GO:0048705 IEA     homeostasis of number of cells within a tissue GO:0048873 IEA     positive regulation of protein secretion GO:0050714 IEA     defense response to Gram-positive bacterium GO:0050830 IEA     release of sequestered calcium ion into cytosol GO:0051209 IEA     positive regulation of cytoskeleton organization GO:0051495 ISS     response to calcium ion GO:0051592 IEA     response to electrical stimulus GO:0051602 IEA     mitochondrial depolarization GO:0051882 IEA     membrane depolarization GO:0051899 IDA     positive regulation of mitochondrial depolarization GO:0051901 IEA     excitatory postsynaptic potential GO:0060079 IEA     positive regulation of macrophage cytokine production GO:0060907 IEA     T cell apoptotic process GO:0070231 IEA     positive regulation of T cell apoptotic process GO:0070234 IEA     calcium ion transmembrane transport GO:0070588 IBA     cellular response to ATP GO:0071318 TAS     cellular response to dsRNA GO:0071359 IEA     reactive oxygen species metabolic process GO:0072593 IEA     apoptotic signaling pathway GO:0097190 ISS     extrinsic apoptotic signaling pathway GO:0097191 ISS     positive regulation of NLRP3 inflammasome complex assembly GO:1900227 ISS     positive regulation of bleb assembly GO:1904172 IMP Subcellular Localization     cytoplasm GO:0005737 ISS     mitochondrion GO:0005739 IEA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IC     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISS     plasma membrane GO:0005886 TAS     cell-cell junction GO:0005911 IEA     external side of plasma membrane GO:0009897 IEA     membrane GO:0016020 IDA     neuromuscular junction GO:0031594 IEA     bleb GO:0032059 ISS     neuronal cell body GO:0043025 IEA     presynapse GO:0098793 IEA     postsynapse GO:0098794 IEA