Gene description for ARHGEF26
Gene name Rho guanine nucleotide exchange factor (GEF) 26
Gene symbol ARHGEF26
Other names/aliases CSGEF
HMFN1864
SGEF
Species Homo sapiens
 Database cross references - ARHGEF26
ExoCarta ExoCarta_26084
Vesiclepedia VP_26084
Entrez Gene 26084
HGNC 24490
UniProt Q96DR7  
 ARHGEF26 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ARHGEF26
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IEA
Biological Process
    endothelial cell morphogenesis GO:0001886 IEA
    regulation of actin cytoskeleton organization GO:0032956 IBA
    ruffle assembly GO:0097178 IEA
Subcellular Localization
    ruffle GO:0001726 IEA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified ARHGEF26 in sEVs
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ARHGEF26
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MRPS7 51081
Affinity Capture-MS Homo sapiens
2 CPT2 1376
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 RBM39 9584
Affinity Capture-MS Homo sapiens
4 PDPR 55066
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 LIN7C 55327
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 MTIF2 4528
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 DLG3 1741
Affinity Capture-MS Homo sapiens
8 CASK 8573
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 MAPK1 5594
Affinity Capture-MS Homo sapiens
10 RSAD1  
Affinity Capture-MS Homo sapiens
11 DLG1 1739
Affinity Capture-MS Homo sapiens
12 PPIB 5479
Affinity Capture-MS Homo sapiens
13 TP53 7157
Affinity Capture-MS Homo sapiens
14 MCCC1 56922
Affinity Capture-MS Homo sapiens
15 XRN2 22803
Affinity Capture-MS Homo sapiens
16 MUT 4594
Affinity Capture-MS Homo sapiens
17 S100A9 6280
Affinity Capture-MS Homo sapiens
18 CPS1 1373
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 CDC42 998
FRET Homo sapiens
20 DCAF8 50717
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 RUVBL1 8607
Affinity Capture-MS Homo sapiens
22 DEK 7913
Affinity Capture-MS Homo sapiens
23 AARS2  
Affinity Capture-MS Homo sapiens
24 ACSF2 80221
Affinity Capture-MS Homo sapiens
25 LIN7B  
Affinity Capture-MS Homo sapiens
26 LUC7L2 51631
Affinity Capture-MS Homo sapiens
27 SCRIB 23513
Affinity Capture-MS Homo sapiens
28 RHOB 388
Proximity Label-MS Homo sapiens
29 RAC1 5879
FRET Homo sapiens
30 SIRT3  
Affinity Capture-MS Homo sapiens
31 APBA1  
Affinity Capture-MS Homo sapiens
32 TMLHE 55217
Affinity Capture-MS Homo sapiens
33 DARS2 55157
Affinity Capture-MS Homo sapiens
34 CKMT1B 1159
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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