Gene description for CPT2
Gene name carnitine palmitoyltransferase 2
Gene symbol CPT2
Other names/aliases CPT1
CPTASE
IIAE4
Species Homo sapiens
 Database cross references - CPT2
ExoCarta ExoCarta_1376
Vesiclepedia VP_1376
Entrez Gene 1376
HGNC 2330
MIM 600650
UniProt P23786  
 CPT2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CPT2
Molecular Function
    carnitine O-palmitoyltransferase activity GO:0004095 EXP
    carnitine O-palmitoyltransferase activity GO:0004095 IBA
    carnitine O-palmitoyltransferase activity GO:0004095 IDA
    carnitine O-palmitoyltransferase activity GO:0004095 NAS
    protein binding GO:0005515 IPI
    carnitine O-octanoyltransferase activity GO:0008458 IEA
    acyltransferase activity GO:0016746 IDA
Biological Process
    long-chain fatty acid metabolic process GO:0001676 IDA
    in utero embryonic development GO:0001701 IEA
    fatty acid beta-oxidation GO:0006635 IBA
    fatty acid beta-oxidation GO:0006635 IDA
    fatty acid beta-oxidation GO:0006635 IEA
    carnitine shuttle GO:0006853 TAS
    carnitine metabolic process GO:0009437 IDA
    positive regulation of cold-induced thermogenesis GO:0120162 ISS
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 NAS
    mitochondrial inner membrane GO:0005743 TAS
 Experiment description of studies that identified CPT2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CPT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TOMM40 10452
Co-fractionation Homo sapiens
2 AK4 205
Affinity Capture-MS Homo sapiens
3 CLPP 8192
Proximity Label-MS Homo sapiens
4 ALDH7A1 501
Co-fractionation Homo sapiens
5 SQRDL 58472
Co-fractionation Homo sapiens
6 APLNR  
Affinity Capture-MS Homo sapiens
7 PARP1 142
Proximity Label-MS Homo sapiens
8 UQCRQ 27089
Co-fractionation Homo sapiens
9 GTF3C3 9330
Co-fractionation Homo sapiens
10 KPNA1 3836
Co-fractionation Homo sapiens
11 ADCK3  
Affinity Capture-MS Homo sapiens
12 SPRED2 200734
Affinity Capture-MS Homo sapiens
13 NDUFA13 51079
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ACSM5 54988
Affinity Capture-MS Homo sapiens
15 ICT1 3396
Affinity Capture-MS Homo sapiens
16 OXLD1  
Affinity Capture-MS Homo sapiens
17 RPA2 6118
Proximity Label-MS Homo sapiens
18 MCL1 4170
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 NUDT13  
Affinity Capture-MS Homo sapiens
20 C2orf47  
Affinity Capture-MS Homo sapiens
21 SLC25A35  
Affinity Capture-MS Homo sapiens
22 COX15 1355
Proximity Label-MS Homo sapiens
23 C17orf89  
Affinity Capture-MS Homo sapiens
24 GPT2  
Affinity Capture-MS Homo sapiens
25 FAHD1 81889
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 ARHGEF26 26084
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 NDUFA4 4697
Affinity Capture-MS Homo sapiens
28 ATP1B3 483
Co-fractionation Homo sapiens
29 SYVN1 84447
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
30 C15orf48  
Affinity Capture-MS Homo sapiens
31 RAB32 10981
Co-fractionation Homo sapiens
32 AMACR 23600
Affinity Capture-MS Homo sapiens
33 SSH3 54961
Affinity Capture-MS Homo sapiens
34 ATP5L 10632
Co-fractionation Homo sapiens
35 HCCS 3052
Co-fractionation Homo sapiens
36 ATF6B  
Affinity Capture-MS Homo sapiens
37 KCTD10 83892
Affinity Capture-MS Homo sapiens
38 ATP5D 513
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 GNAS 2778
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 NDUFS3 4722
Affinity Capture-MS Homo sapiens
41 RNMTL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 RPA3 6119
Proximity Label-MS Homo sapiens
43 COQ9  
Affinity Capture-MS Homo sapiens
44 PTPMT1 114971
Affinity Capture-MS Homo sapiens
45 ATP1B1 481
Co-fractionation Homo sapiens
46 YARS2  
Affinity Capture-MS Homo sapiens
47 QRSL1  
Affinity Capture-MS Homo sapiens
48 GCAT  
Affinity Capture-MS Homo sapiens
49 ARG2  
Affinity Capture-MS Homo sapiens
50 PSMC6 5706
Co-fractionation Homo sapiens
51 C21orf33  
Proximity Label-MS Homo sapiens
52 GAPVD1 26130
Co-fractionation Homo sapiens
53 TMEM70  
Affinity Capture-MS Homo sapiens
54 MCUR1 63933
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 SCCPDH 51097
Co-fractionation Homo sapiens
56 SLC25A10 1468
Affinity Capture-MS Homo sapiens
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