Gene description for MBL2
Gene name mannose-binding lectin (protein C) 2, soluble
Gene symbol MBL2
Other names/aliases COLEC1
HSMBPC
MBL
MBL2D
MBP
MBP-C
MBP1
MBPD
Species Homo sapiens
 Database cross references - MBL2
ExoCarta ExoCarta_4153
Vesiclepedia VP_4153
Entrez Gene 4153
HGNC 6922
MIM 154545
UniProt P11226  
 MBL2 identified in sEVs derived from the following tissue/cell type
Plasma 19028452    
 Gene ontology annotations for MBL2
Molecular Function
    signaling receptor binding GO:0005102 IPI
    protein binding GO:0005515 IPI
    D-mannose binding GO:0005537 IDA
    D-mannose binding GO:0005537 NAS
    D-mannose binding GO:0005537 TAS
    identical protein binding GO:0042802 IPI
    calcium-dependent protein binding GO:0048306 IPI
Biological Process
    complement activation, lectin pathway GO:0001867 IDA
    complement activation, lectin pathway GO:0001867 IDA
    complement activation, lectin pathway GO:0001867 IPI
    cell surface pattern recognition receptor signaling pathway GO:0002752 IDA
    proteolysis GO:0006508 IDA
    acute-phase response GO:0006953 TAS
    complement activation, classical pathway GO:0006958 IEA
    response to oxidative stress GO:0006979 NAS
    opsonization GO:0008228 TAS
    defense response to bacterium GO:0042742 TAS
    surfactant homeostasis GO:0043129 IBA
    innate immune response GO:0045087 IDA
    negative regulation of viral process GO:0048525 IDA
    positive regulation of phagocytosis GO:0050766 IBA
    defense response to Gram-positive bacterium GO:0050830 IDA
    killing by host of symbiont cells GO:0051873 IEA
    antiviral innate immune response GO:0140374 IDA
    positive regulation of opsonization GO:1903028 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    collagen trimer GO:0005581 IEA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 NAS
    multivesicular body GO:0005771 IBA
    external side of plasma membrane GO:0009897 NAS
    cell surface GO:0009986 TAS
    serine-type endopeptidase complex GO:1905370 IPI
 Experiment description of studies that identified MBL2 in sEVs
1
Experiment ID 44
MISEV standards
IEM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19028452    
Organism Homo sapiens
Experiment description Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Authors "Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ"
Journal name BBRC
Publication year 2009
Sample Plasma
Sample name Plasma
Isolation/purification methods Filtration
Size exclusion
Sucrose density gradient
Flotation density 1.15-1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for MBL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAPPC2 6399
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 PSMB2 5690
Affinity Capture-MS Homo sapiens
3 MASP2 10747
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
4 CALR 811
Reconstituted Complex Homo sapiens
5 PSMA6 5687
Affinity Capture-MS Homo sapiens
6 PSMA3 5684
Affinity Capture-MS Homo sapiens
7 KRT1 3848
Affinity Capture-Western Homo sapiens
8 DCK 1633
Affinity Capture-MS Homo sapiens
9 PSMB3 5691
Affinity Capture-MS Homo sapiens
10 MASP1 5648
Affinity Capture-Western Homo sapiens
11 EGLN3  
Affinity Capture-MS Homo sapiens
12 TGIF2LX  
Affinity Capture-MS Homo sapiens
13 UBQLN2 29978
Two-hybrid Homo sapiens
14 PSMB7 5695
Affinity Capture-MS Homo sapiens
15 PSMB4 5692
Affinity Capture-MS Homo sapiens
16 PSMA2 5683
Affinity Capture-MS Homo sapiens
17 FUBP3 8939
Affinity Capture-MS Homo sapiens
18 PCGF3  
Affinity Capture-MS Homo sapiens
19 PSMA1 5682
Affinity Capture-MS Homo sapiens
20 RASL11A  
Affinity Capture-MS Homo sapiens
21 TRMU  
Affinity Capture-MS Homo sapiens
22 GALNT9  
Affinity Capture-MS Homo sapiens
23 SPIN4  
Affinity Capture-MS Homo sapiens
24 UBE2J2 118424
Affinity Capture-MS Homo sapiens
25 FBXO11  
Affinity Capture-MS Homo sapiens
26 PSMB1 5689
Affinity Capture-MS Homo sapiens
27 PDIA5 10954
Affinity Capture-MS Homo sapiens
28 PSME4 23198
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here