Gene description for MPV17
Gene name MpV17 mitochondrial inner membrane protein
Gene symbol MPV17
Other names/aliases MTDPS6
SYM1
Species Homo sapiens
 Database cross references - MPV17
ExoCarta ExoCarta_4358
Vesiclepedia VP_4358
Entrez Gene 4358
HGNC 7224
MIM 137960
UniProt P39210  
 MPV17 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MPV17
Molecular Function
    channel activity GO:0015267 IBA
    channel activity GO:0015267 IMP
Biological Process
    mitochondrial genome maintenance GO:0000002 IMP
    glomerular basement membrane development GO:0032836 ISS
    cellular response to reactive oxygen species GO:0034614 ISS
    homeostatic process GO:0042592 IMP
    inner ear development GO:0048839 ISS
    transmembrane transport GO:0055085 IEA
    regulation of mitochondrial DNA metabolic process GO:1901858 IBA
    regulation of mitochondrial DNA metabolic process GO:1901858 IMP
    regulation of reactive oxygen species metabolic process GO:2000377 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IDA
    peroxisome GO:0005777 IDA
    peroxisome GO:0005777 NAS
    peroxisomal membrane GO:0005778 TAS
    cytosol GO:0005829 TAS
 Experiment description of studies that identified MPV17 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MPV17
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SCFD1 23256
Co-fractionation Homo sapiens
2 UQCRFS1 7386
Co-fractionation Homo sapiens
3 SLC25A24 29957
Co-fractionation Homo sapiens
4 MRPL44  
Co-fractionation Homo sapiens
5 MRPL40 64976
Co-fractionation Homo sapiens
6 ATP6V1F 9296
Co-fractionation Homo sapiens
7 MRPL11 65003
Co-fractionation Homo sapiens
8 NDUFB5 4711
Co-fractionation Homo sapiens
9 MRPL17  
Co-fractionation Homo sapiens
10 UQCRH 7388
Co-fractionation Homo sapiens
11 MRPL13  
Co-fractionation Homo sapiens
12 NDUFB7 4713
Co-fractionation Homo sapiens
13 MRPL32 64983
Co-fractionation Homo sapiens
14 FAM3C 10447
Co-fractionation Homo sapiens
15 ATP6V1D 51382
Co-fractionation Homo sapiens
16 RPS15 6209
Co-fractionation Homo sapiens
17 EGFR 1956
Co-fractionation Homo sapiens
18 VHL  
Negative Genetic Homo sapiens
19 HNRNPR 10236
Co-fractionation Homo sapiens
20 NDUFA4 4697
Affinity Capture-MS Homo sapiens
21 PUF60 22827
Co-fractionation Homo sapiens
22 SFXN3 81855
Co-fractionation Homo sapiens
23 RALA 5898
Co-fractionation Homo sapiens
24 MMGT1 93380
Co-fractionation Homo sapiens
25 VDAC2 7417
Co-fractionation Homo sapiens
26 APEX1 328
Affinity Capture-RNA Homo sapiens
27 NDUFS7 374291
Co-fractionation Homo sapiens
28 PTCD3 55037
Co-fractionation Homo sapiens
29 NDUFB9 4715
Co-fractionation Homo sapiens
30 MRPL22  
Co-fractionation Homo sapiens
31 NDUFS8 4728
Co-fractionation Homo sapiens
32 MOV10 4343
Affinity Capture-RNA Homo sapiens
33 HNRNPL 3191
Co-fractionation Homo sapiens
34 MRPL51 51258
Co-fractionation Homo sapiens
35 MSLN 10232
Co-fractionation Homo sapiens
36 CYB5R1 51706
Co-fractionation Homo sapiens
37 MRPL23 6150
Co-fractionation Homo sapiens
38 NDUFB6 4712
Co-fractionation Homo sapiens
39 MRPS16  
Co-fractionation Homo sapiens
40 STK11 6794
Negative Genetic Homo sapiens
41 PEX5 5830
Protein-peptide Homo sapiens
42 NDUFS6  
Co-fractionation Homo sapiens
43 ABCD3 5825
Co-fractionation Homo sapiens
44 NDUFA12 55967
Co-fractionation Homo sapiens
45 CD55 1604
Co-fractionation Homo sapiens
46 MRPL38  
Co-fractionation Homo sapiens
47 RHOA 387
Co-fractionation Homo sapiens
48 LAMTOR3 8649
Co-fractionation Homo sapiens
49 MRPS14  
Co-fractionation Homo sapiens
50 NDUFA10 4705
Co-fractionation Homo sapiens
51 GPRC5A 9052
Co-fractionation Homo sapiens
52 NDUFB4 4710
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which MPV17 is involved
PathwayEvidenceSource
Peroxisomal protein import IEA Reactome
Peroxisomal protein import TAS Reactome
Protein localization IEA Reactome
Protein localization TAS Reactome





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