Gene description for Lats2
Gene name	large tumor suppressor 2
Gene symbol	Lats2
Other names/aliases	4932411G09Rik AV277261 AW228608
Species	Mus musculus
Database cross references - Lats2
ExoCarta	ExoCarta_50523
Vesiclepedia	VP_50523
Entrez Gene	50523
UniProt	Q7TSJ6
Lats2 identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Lats2

Molecular Function     protein serine/threonine kinase activity GO:0004674 IBA     protein serine/threonine kinase activity GO:0004674 IDA     protein serine/threonine kinase activity GO:0004674 ISO     protein serine/threonine kinase activity GO:0004674 ISS     3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA     DNA-dependent protein kinase activity GO:0004677 IEA     AMP-activated protein kinase activity GO:0004679 IEA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA     ribosomal protein S6 kinase activity GO:0004711 IEA     ATP binding GO:0005524 ISO     ATP binding GO:0005524 ISS     histone H3S10 kinase activity GO:0035175 IEA     histone H3T11 kinase activity GO:0035402 IEA     histone H3T6 kinase activity GO:0035403 IEA     histone H2AXS139 kinase activity GO:0035979 IEA     histone H3S28 kinase activity GO:0044022 IEA     histone H4S1 kinase activity GO:0044023 IEA     histone H2AS1 kinase activity GO:0044024 IEA     histone H2BS14 kinase activity GO:0044025 IEA     metal ion binding GO:0046872 IEA     histone H3T3 kinase activity GO:0072354 IEA     histone H2AS121 kinase activity GO:0072371 IEA     Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA     protein serine kinase activity GO:0106310 IEA     histone H2BS36 kinase activity GO:0140823 IEA     histone H3S57 kinase activity GO:0140855 IEA     histone H3T45 kinase activity GO:0140857 IEA     histone H2AT120 kinase activity GO:1990244 IEA Biological Process     G1/S transition of mitotic cell cycle GO:0000082 IBA     G1/S transition of mitotic cell cycle GO:0000082 IDA     G1/S transition of mitotic cell cycle GO:0000082 ISO     inner cell mass cell fate commitment GO:0001827 IGI     inner cell mass cellular morphogenesis GO:0001828 IGI     chromatin remodeling GO:0006338 IEA     protein phosphorylation GO:0006468 IDA     protein phosphorylation GO:0006468 ISO     protein phosphorylation GO:0006468 ISS     protein localization GO:0008104 IDA     protein localization GO:0008104 IGI     hormone-mediated signaling pathway GO:0009755 ISO     hormone-mediated signaling pathway GO:0009755 ISS     regulation of transforming growth factor beta receptor signaling pathway GO:0017015 IMP     keratinocyte differentiation GO:0030216 IGI     hippo signaling GO:0035329 IBA     hippo signaling GO:0035329 IGI     hippo signaling GO:0035329 ISO     intracellular signal transduction GO:0035556 ISO     intracellular signal transduction GO:0035556 ISS     positive regulation of apoptotic process GO:0043065 IBA     negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 ISO     negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 ISS     regulation of organ growth GO:0046620 IBA     regulation of organ growth GO:0046620 IMP     cell division GO:0051301 IEA     canonical Wnt signaling pathway GO:0060070 IGI     negative regulation of canonical Wnt signaling pathway GO:0090090 IGI     negative regulation of canonical Wnt signaling pathway GO:0090090 ISO     negative regulation of protein localization to nucleus GO:1900181 IMP     positive regulation of NLRP3 inflammasome complex assembly GO:1900227 IDA Subcellular Localization     spindle pole GO:0000922 IBA     spindle pole GO:0000922 IDA     spindle pole GO:0000922 ISO     nucleus GO:0005634 IBA     nucleus GO:0005634 ISO     cytoplasm GO:0005737 ISO     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     centriolar satellite GO:0034451 IEA     centriolar satellite GO:0034451 ISO