Gene description for Slc25a13
Gene name solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
Gene symbol Slc25a13
Other names/aliases AI785475
Ctrn
Species Mus musculus
 Database cross references - Slc25a13
ExoCarta ExoCarta_50799
Vesiclepedia VP_50799
Entrez Gene 50799
UniProt Q9QXX4  
 Slc25a13 identified in sEVs derived from the following tissue/cell type
Melanoma cells 34957415    
Melanoma cells 34957415    
 Gene ontology annotations for Slc25a13
Molecular Function
    3-sulfino-L-alanine: proton, glutamate antiporter activity GO:0000514 ISO
    3-sulfino-L-alanine: proton, glutamate antiporter activity GO:0000514 ISS
    aspartate:glutamate, proton antiporter activity GO:0000515 ISO
    aspartate:glutamate, proton antiporter activity GO:0000515 ISS
    L-glutamate transmembrane transporter activity GO:0005313 IBA
    L-glutamate transmembrane transporter activity GO:0005313 IMP
    calcium ion binding GO:0005509 ISO
    calcium ion binding GO:0005509 ISS
    acidic amino acid transmembrane transporter activity GO:0015172 IMP
    acidic amino acid transmembrane transporter activity GO:0015172 ISO
    L-aspartate transmembrane transporter activity GO:0015183 IBA
    identical protein binding GO:0042802 ISO
    identical protein binding GO:0042802 ISS
Biological Process
    gluconeogenesis GO:0006094 IMP
    ATP biosynthetic process GO:0006754 IEA
    ATP biosynthetic process GO:0006754 ISO
    neutral amino acid transport GO:0015804 IEA
    aspartate transmembrane transport GO:0015810 IBA
    aspartate transmembrane transport GO:0015810 IMP
    aspartate transmembrane transport GO:0015810 ISO
    L-glutamate transmembrane transport GO:0015813 IBA
    L-glutamate transmembrane transport GO:0015813 ISO
    L-glutamate transmembrane transport GO:0015813 ISS
    malate-aspartate shuttle GO:0043490 IBA
    malate-aspartate shuttle GO:0043490 IMP
    malate-aspartate shuttle GO:0043490 ISO
    cellular respiration GO:0045333 ISO
    response to calcium ion GO:0051592 ISO
    response to calcium ion GO:0051592 ISS
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 IMP
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 HDA
    mitochondrial inner membrane GO:0005743 IMP
    mitochondrial inner membrane GO:0005743 ISO
    mitochondrial inner membrane GO:0005743 TAS
 Experiment description of studies that identified Slc25a13 in sEVs
1
Experiment ID 1117
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 1118
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Slc25a13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Nphs2  
Affinity Capture-MS Mus musculus
2 SNCA 6622
Affinity Capture-MS Homo sapiens
3 Slc25a4 11739
Cross-Linking-MS (XL-MS) Mus musculus
4 Eed  
Affinity Capture-MS Mus musculus
5 Cox6c  
Cross-Linking-MS (XL-MS) Mus musculus
6 Slc25a13 50799
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
7 Slc25a12  
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
8 Atg16l1  
Affinity Capture-MS Mus musculus
9 Cyct  
Cross-Linking-MS (XL-MS) Mus musculus
10 Pcca  
Cross-Linking-MS (XL-MS) Mus musculus
11 Dync1i1  
Affinity Capture-Western Mus musculus
12 Nanog  
Affinity Capture-MS Mus musculus
13 Fancd2  
Affinity Capture-MS Mus musculus
14 Cycs 13063
Cross-Linking-MS (XL-MS) Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here