Gene description for PKD1
Gene name	polycystic kidney disease 1 (autosomal dominant)
Gene symbol	PKD1
Other names/aliases	PBP Pc-1 TRPP1
Species	Homo sapiens
Database cross references - PKD1
ExoCarta	ExoCarta_5310
Vesiclepedia	VP_5310
Entrez Gene	5310
HGNC	9008
MIM	601313
UniProt	P98161
PKD1 identified in sEVs derived from the following tissue/cell type
Urine	15326289
Urine	19056867

Gene ontology annotations for PKD1

Molecular Function     monoatomic cation channel activity GO:0005261 IBA     calcium channel activity GO:0005262 IDA     calcium channel activity GO:0005262 ISS     protein binding GO:0005515 IPI     protein kinase binding GO:0019901 IPI     protein domain specific binding GO:0019904 IPI     carbohydrate binding GO:0030246 IEA     Wnt receptor activity GO:0042813 IDA     transmembrane transporter binding GO:0044325 IPI     transcription regulator inhibitor activity GO:0140416 ISS Biological Process     cartilage condensation GO:0001502 IEA     in utero embryonic development GO:0001701 ISS     kidney development GO:0001822 ISS     liver development GO:0001889 IEA     embryonic placenta development GO:0001892 ISS     protein export from nucleus GO:0006611 ISS     calcium ion transport GO:0006816 IBA     calcium ion transport GO:0006816 IDA     homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 TAS     cell-matrix adhesion GO:0007160 TAS     calcium-independent cell-matrix adhesion GO:0007161 TAS     cell surface receptor signaling pathway GO:0007166 IDA     positive regulation of cytosolic calcium ion concentration GO:0007204 IEA     cell surface receptor signaling pathway via JAK-STAT GO:0007259 ISO     cell surface receptor signaling pathway via JAK-STAT GO:0007259 ISS     heart development GO:0007507 IEP     anatomical structure morphogenesis GO:0009653 TAS     Wnt signaling pathway GO:0016055 IDA     peptidyl-serine phosphorylation GO:0018105 ISS     spinal cord development GO:0021510 IEP     neural tube development GO:0021915 IEP     regulation of cell adhesion GO:0030155 IEA     response to fluid shear stress GO:0034405 IEA     lymph vessel morphogenesis GO:0036303 IEA     skin development GO:0043588 IEP     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     digestive tract development GO:0048565 IEP     branching morphogenesis of an epithelial tube GO:0048754 IDA     genitalia development GO:0048806 IEP     detection of mechanical stimulus GO:0050982 ISS     cartilage development GO:0051216 IEP     protein heterotetramerization GO:0051290 IDA     regulation of cell cycle GO:0051726 ISS     regulation of mitotic spindle organization GO:0060236 IEA     lung epithelium development GO:0060428 IEP     placenta blood vessel development GO:0060674 ISS     regulation of proteasomal protein catabolic process GO:0061136 IDA     calcium ion transmembrane transport GO:0070588 ISS     nitrogen cycle metabolic process GO:0071941 IEA     mesonephric tubule development GO:0072164 IEP     mesonephric duct development GO:0072177 IEP     metanephric collecting duct development GO:0072205 IEP     metanephric ascending thin limb development GO:0072218 IEP     metanephric proximal tubule development GO:0072237 IEP     metanephric distal tubule morphogenesis GO:0072287 IEP     establishment of epithelial cell polarity GO:0090162 IEA     mitocytosis GO:0160040 IDA     regulation of G1/S transition of mitotic cell cycle GO:2000045 IDA Subcellular Localization     Golgi membrane GO:0000139 TAS     polycystin complex GO:0002133 IPI     polycystin complex GO:0002133 ISS     nucleus GO:0005634 ISS     cytoplasm GO:0005737 ISS     endoplasmic reticulum GO:0005783 ISS     Golgi apparatus GO:0005794 ISS     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     cilium GO:0005929 IDA     cilium GO:0005929 ISO     cilium GO:0005929 ISS     cell surface GO:0009986 IEA     membrane GO:0016020 IDA     membrane GO:0016020 NAS     basolateral plasma membrane GO:0016323 IDA     lateral plasma membrane GO:0016328 IEA     Golgi-associated vesicle membrane GO:0030660 TAS     motile cilium GO:0031514 ISS     cation channel complex GO:0034703 IDA     calcium channel complex GO:0034704 IDA     ciliary membrane GO:0060170 TAS     extracellular exosome GO:0070062 HDA     extracellular exosome GO:0070062 IDA     migrasome GO:0140494 IDA