Gene description for FXYD1
Gene name FXYD domain containing ion transport regulator 1
Gene symbol FXYD1
Other names/aliases PLM
Species Homo sapiens
 Database cross references - FXYD1
ExoCarta ExoCarta_5348
Vesiclepedia VP_5348
Entrez Gene 5348
HGNC 4025
MIM 602359
UniProt O00168  
 FXYD1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for FXYD1
Molecular Function
    chloride channel activity GO:0005254 TAS
    sodium channel regulator activity GO:0017080 IBA
    sodium channel regulator activity GO:0017080 ISS
    transmembrane transporter binding GO:0044325 ISS
Biological Process
    potassium ion transport GO:0006813 IEA
    sodium ion transport GO:0006814 IEA
    chloride transport GO:0006821 TAS
    muscle contraction GO:0006936 TAS
    regulation of heart contraction GO:0008016 TAS
    negative regulation of protein glutathionylation GO:0010734 ISS
    regulation of cardiac muscle cell membrane potential GO:0086036 ISS
    chloride transmembrane transport GO:1902476 IEA
    positive regulation of sodium ion export across plasma membrane GO:1903278 IBA
    positive regulation of sodium ion export across plasma membrane GO:1903278 ISS
    regulation of sodium ion transmembrane transporter activity GO:2000649 ISS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    sodium:potassium-exchanging ATPase complex GO:0005890 ISS
    caveola GO:0005901 ISS
    intercalated disc GO:0014704 ISS
    apical plasma membrane GO:0016324 ISS
    T-tubule GO:0030315 ISS
    sarcolemma GO:0042383 ISS
 Experiment description of studies that identified FXYD1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FXYD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATP1B1 481
Affinity Capture-Western Homo sapiens
2 GCHFR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 ATP6V1D 51382
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 YWHAQ 10971
Reconstituted Complex Homo sapiens
5 POLE4  
Affinity Capture-MS Homo sapiens
6 NDRG4 65009
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 PRTFDC1 56952
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 SPINK4  
Affinity Capture-MS Homo sapiens
9 PTTG1  
Synthetic Growth Defect Homo sapiens
10 FAM204A  
Affinity Capture-MS Homo sapiens
11 NDRG1 10397
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 ATP1A1 476
Affinity Capture-Western Homo sapiens
13 GOPC 57120
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 NDRG3 57446
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 THNSL1 79896
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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