Gene description for PRTFDC1
Gene name phosphoribosyl transferase domain containing 1
Gene symbol PRTFDC1
Other names/aliases HHGP
Species Homo sapiens
 Database cross references - PRTFDC1
ExoCarta ExoCarta_56952
Vesiclepedia VP_56952
Entrez Gene 56952
HGNC 23333
MIM 610751
UniProt Q9NRG1  
 PRTFDC1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PRTFDC1
Molecular Function
    nucleotide binding GO:0000166 IEA
    magnesium ion binding GO:0000287 TAS
    hypoxanthine phosphoribosyltransferase activity GO:0004422 IDA
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IPI
Biological Process
    purine ribonucleoside salvage GO:0006166 IEA
    guanine salvage GO:0006178 IDA
    GMP catabolic process GO:0046038 IDA
Subcellular Localization
    cytosol GO:0005829 IBA
 Experiment description of studies that identified PRTFDC1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PRTFDC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MCMBP 79892
Two-hybrid Homo sapiens
2 HSD17B6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 EPM2AIP1 9852
Two-hybrid Homo sapiens
4 NIF3L1 60491
Two-hybrid Homo sapiens
5 MED7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 SPRED2 200734
Affinity Capture-MS Homo sapiens
7 STAT5A 6776
Two-hybrid Homo sapiens
8 MYEOV  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SPINK2  
Affinity Capture-MS Homo sapiens
10 NFKBIA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 RTN3 10313
Co-fractionation Homo sapiens
12 TMEM14B  
Two-hybrid Homo sapiens
13 TCL1A  
Two-hybrid Homo sapiens
14 LGALS9B 284194
Two-hybrid Homo sapiens
15 IL36RN  
Affinity Capture-MS Homo sapiens
16 FCGR2A 2212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 IQCF1  
Affinity Capture-MS Homo sapiens
18 SOX2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 EEF2KMT  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
20 DTNB 1838
Two-hybrid Homo sapiens
21 C9orf85  
Affinity Capture-MS Homo sapiens
22 HPRT1 3251
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
23 EWSR1 2130
Two-hybrid Homo sapiens
24 FLAD1 80308
Two-hybrid Homo sapiens
25 GNPDA1 10007
Two-hybrid Homo sapiens
26 STPG1  
Affinity Capture-MS Homo sapiens
27 FXYD1 5348
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PRTFDC1 is involved
No pathways found





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