Gene description for Vti1a
Gene name vesicle transport through interaction with t-SNAREs 1A
Gene symbol Vti1a
Other names/aliases 1110014F16Rik
1110018K19Rik
4921537J05Rik
MVti1
MVti1a
Vti1
Vti1-rp2
Species Mus musculus
 Database cross references - Vti1a
ExoCarta ExoCarta_53611
Vesiclepedia VP_53611
Entrez Gene 53611
UniProt O89116  
 Vti1a identified in sEVs derived from the following tissue/cell type
Microglia 16081791    
 Gene ontology annotations for Vti1a
Molecular Function
    SNARE binding GO:0000149 IBA
    SNAP receptor activity GO:0005484 IBA
    SNAP receptor activity GO:0005484 IEA
    SNAP receptor activity GO:0005484 ISO
Biological Process
    intracellular protein transport GO:0006886 IEA
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 ISO
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 ISS
    intra-Golgi vesicle-mediated transport GO:0006891 IBA
    Golgi to vacuole transport GO:0006896 IBA
    autophagy GO:0006914 ISO
    synaptic vesicle to endosome fusion GO:0016189 ISO
    macroautophagy GO:0016236 IBA
    endocytic recycling GO:0032456 ISO
    retrograde transport, endosome to Golgi GO:0042147 IBA
    retrograde transport, endosome to Golgi GO:0042147 ISO
    retrograde transport, endosome to Golgi GO:0042147 ISS
    vesicle fusion with Golgi apparatus GO:0048280 IBA
    vesicle fusion with Golgi apparatus GO:0048280 ISO
    vesicle fusion with Golgi apparatus GO:0048280 ISS
    voluntary musculoskeletal movement GO:0050882 ISO
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    endosome GO:0005768 ISS
    autophagosome GO:0005776 ISO
    endoplasmic reticulum membrane GO:0005789 IBA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 ISO
    cytosol GO:0005829 IEA
    synaptic vesicle GO:0008021 ISO
    synaptic vesicle GO:0008021 ISO
    synaptic vesicle GO:0008021 ISS
    ER to Golgi transport vesicle membrane GO:0012507 IBA
    clathrin-coated vesicle GO:0030136 ISO
    clathrin-coated vesicle GO:0030136 ISS
    SNARE complex GO:0031201 IBA
    SNARE complex GO:0031201 ISO
    SNARE complex GO:0031201 ISS
    late endosome membrane GO:0031902 IBA
    neuronal cell body GO:0043025 ISO
    neuronal cell body GO:0043025 ISS
    intracellular membrane-bounded organelle GO:0043231 ISO
    neuron projection terminus GO:0044306 ISO
    neuron projection terminus GO:0044306 ISS
    perinuclear region of cytoplasm GO:0048471 ISO
    perinuclear region of cytoplasm GO:0048471 ISS
    hippocampal mossy fiber to CA3 synapse GO:0098686 ISO
 Experiment description of studies that identified Vti1a in sEVs
1
Experiment ID 14
MISEV standards
EM
Biophysical techniques
RAB7|RAB11|CD9|CD63|LAMP1|LAMP2
Enriched markers
DNM
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors "Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L"
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
 Protein-protein interactions for Vti1a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Stx6  
Affinity Capture-Western Mus musculus
2 Timm8b  
Co-fractionation Mus musculus
3 Uggt1 320011
Co-fractionation Mus musculus
4 Stx12  
Co-fractionation Mus musculus
5 Stx7  
Affinity Capture-Western Mus musculus
6 Obscn  
Co-fractionation Mus musculus
7 Vps51  
Co-fractionation Mus musculus
View the network image/svg+xml



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