Experiment description of studies that identified CCSER2 in sEVs

1 Experiment ID 494 MISEV standards ✔ EM Biophysical techniques ✔ CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101 Enriched markers ✘ Negative markers ✔ NTA Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 35931686     Organism Homo sapiens Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD." Journal name Cell Death Dis Publication year 2022 Sample Chondrocytes Sample name Osteoarthritic cartilage Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectometry

2 Experiment ID 496 MISEV standards ✘ Biophysical techniques ✔ CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101 Enriched markers ✘ Negative markers ✘ Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 35931686     Organism Homo sapiens Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD." Journal name Cell Death Dis Publication year 2022 Sample Chondrocytes Sample name Healthy cartilage Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectometry

Protein-protein interactions for CCSER2

Protein Interactor ExoCarta ID Identification method PubMed Species 1 YWHAH 7533 Affinity Capture-MS Homo sapiens 2 APP 351 Reconstituted Complex Homo sapiens 3 PAFAH1B1 5048 Proximity Label-MS Homo sapiens 4 RNF43   Proximity Label-MS Homo sapiens 5 DYNC1I2 1781 Proximity Label-MS Homo sapiens 6 MAPRE1 22919 Proximity Label-MS Homo sapiens Affinity Capture-MS Homo sapiens 7 DYNLL2 140735 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 8 SIRT6   Affinity Capture-MS Homo sapiens 9 SLMAP 7871 Proximity Label-MS Homo sapiens 10 OCLN 100506658 Proximity Label-MS Homo sapiens 11 PSMD11 5717 Two-hybrid Homo sapiens 12 KRT8 3856 Proximity Label-MS Homo sapiens 13 Bbs5   Two-hybrid Mus musculus 14 MAP1LC3B 81631 Two-hybrid Homo sapiens 15 KIFAP3 22920 Two-hybrid Homo sapiens 16 TCEA2   Two-hybrid Homo sapiens 17 Ndel1   Affinity Capture-MS Mus musculus 18 DNAJC2 27000 Proximity Label-MS Homo sapiens 19 Nde1   Affinity Capture-MS Mus musculus 20 OFD1 8481 Two-hybrid Homo sapiens 21 MAPRE3   Proximity Label-MS Homo sapiens 22 CDH1 999 Proximity Label-MS Homo sapiens 23 MYO6 4646 Proximity Label-MS Homo sapiens 24 STX1A 6804 Two-hybrid Homo sapiens 25 PARD3 56288 Proximity Label-MS Homo sapiens 26 Pafah1b1 18472 Affinity Capture-MS Mus musculus 27 EXOC1 55763 Two-hybrid Homo sapiens 28 CEP135   Proximity Label-MS Homo sapiens 29 GOLGA1   Proximity Label-MS Homo sapiens 30 NDEL1 81565 Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 31 DCTN1 1639 Proximity Label-MS Homo sapiens 32 YWHAQ 10971 Affinity Capture-MS Homo sapiens 33 AMOT 154796 Proximity Label-MS Homo sapiens 34 Ankrd26   Affinity Capture-MS Mus musculus 35 YWHAG 7532 Affinity Capture-MS Homo sapiens 36 GTF2H1 2965 Two-hybrid Homo sapiens 37 ATRX 546 Two-hybrid Homo sapiens 38 BRK1 55845 Affinity Capture-MS Homo sapiens 39 DNAJB5   Proximity Label-MS Homo sapiens 40 PICALM 8301 Affinity Capture-MS Homo sapiens 41 DYNLL1 8655 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 42 EXOSC8   Two-hybrid Homo sapiens 43 CRADD   Two-hybrid Homo sapiens View the network

Pathways in which CCSER2 is involved

No pathways found