Gene description for TBC1D23
Gene name TBC1 domain family, member 23
Gene symbol TBC1D23
Other names/aliases NS4ATP1
Species Homo sapiens
 Database cross references - TBC1D23
ExoCarta ExoCarta_55773
Vesiclepedia VP_55773
Entrez Gene 55773
HGNC 25622
UniProt Q9NUY8  
 TBC1D23 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TBC1D23
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    brain development GO:0007420 IMP
    vesicle-mediated transport GO:0016192 ISS
    neuron projection development GO:0031175 ISS
    retrograde transport, endosome to Golgi GO:0042147 IBA
    retrograde transport, endosome to Golgi GO:0042147 IMP
    vesicle tethering to Golgi GO:0099041 IBA
    vesicle tethering to Golgi GO:0099041 IDA
    embryonic brain development GO:1990403 IBA
    embryonic brain development GO:1990403 ISS
Subcellular Localization
    Golgi apparatus GO:0005794 IDA
    trans-Golgi network GO:0005802 IBA
    trans-Golgi network GO:0005802 IDA
    cytosol GO:0005829 IEA
    cytoplasmic vesicle GO:0031410 IDA
    WASH complex GO:0071203 IDA
 Experiment description of studies that identified TBC1D23 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TBC1D23
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EIF1AD 84285
Affinity Capture-MS Homo sapiens
2 ARL2 402
Affinity Capture-MS Homo sapiens
3 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
4 IPO5 3843
Co-fractionation Homo sapiens
5 SLAMF7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 LAMTOR1 55004
Proximity Label-MS Homo sapiens
7 HSPA8 3312
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ATG9A 79065
Proximity Label-MS Homo sapiens
9 BAG2 9532
Affinity Capture-MS Homo sapiens
10 FOXP1 27086
Protein-RNA Homo sapiens
11 KRTAP10-8  
Two-hybrid Homo sapiens
12 FLYWCH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 S100A2 6273
Affinity Capture-MS Homo sapiens
14 HS2ST1 9653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 EHD2 30846
Two-hybrid Homo sapiens
16 NIPAL1  
Affinity Capture-MS Homo sapiens
17 OSGEP 55644
Co-fractionation Homo sapiens
18 HOOK3 84376
Proximity Label-MS Homo sapiens
19 C12orf45  
Two-hybrid Homo sapiens
20 TNFAIP6 7130
Affinity Capture-MS Homo sapiens
21 KRTAP10-3  
Two-hybrid Homo sapiens
22 FAM174A 345757
Affinity Capture-MS Homo sapiens
23 KBTBD7  
Affinity Capture-MS Homo sapiens
24 SSBP3  
Two-hybrid Homo sapiens
25 CAGE1 285782
Two-hybrid Homo sapiens
26 HYOU1 10525
Affinity Capture-MS Homo sapiens
27 WDR62  
Two-hybrid Homo sapiens
28 KRTAP4-12  
Two-hybrid Homo sapiens
29 API5 8539
Co-fractionation Homo sapiens
30 NPDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 MYPOP  
Affinity Capture-MS Homo sapiens
32 GOLGA1  
Proximity Label-MS Homo sapiens
33 HOXB8  
Affinity Capture-MS Homo sapiens
34 STK11 6794
Two-hybrid Homo sapiens
35 GLRX3 10539
Co-fractionation Homo sapiens
36 PTGES3 10728
Affinity Capture-MS Homo sapiens
37 HSF2BP  
Affinity Capture-MS Homo sapiens
38 KIF4A 24137
Affinity Capture-MS Homo sapiens
39 KRTAP10-9  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TBC1D23 is involved
No pathways found





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