Gene description for SPATA7
Gene name spermatogenesis associated 7
Gene symbol SPATA7
Other names/aliases HEL-S-296
HSD-3.1
HSD3
LCA3
Species Homo sapiens
 Database cross references - SPATA7
ExoCarta ExoCarta_55812
Vesiclepedia VP_55812
Entrez Gene 55812
HGNC 20423
MIM 609868
UniProt Q9P0W8  
 SPATA7 identified in sEVs derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for SPATA7
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    microtubule cytoskeleton organization GO:0000226 IBA
    visual perception GO:0007601 IEA
    photoreceptor cell maintenance GO:0045494 IBA
    photoreceptor cell maintenance GO:0045494 ISS
    protein localization to photoreceptor outer segment GO:1903546 ISS
    protein localization to photoreceptor connecting cilium GO:1903621 ISS
Subcellular Localization
    cytosol GO:0005829 IDA
    axoneme GO:0005930 IBA
    axoneme GO:0005930 IDA
    microtubule cytoskeleton GO:0015630 IDA
    photoreceptor connecting cilium GO:0032391 ISS
    ciliary basal body GO:0036064 IBA
    ciliary basal body GO:0036064 IDA
    rod photoreceptor outer segment GO:0120200 IBA
    photoreceptor distal connecting cilium GO:0120206 IBA
 Experiment description of studies that identified SPATA7 in sEVs
1
Experiment ID 191
MISEV standards
Biophysical techniques
Alix|CD81|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SPATA7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NEK1  
Affinity Capture-MS Homo sapiens
2 APP 351
Reconstituted Complex Homo sapiens
3 CYB5R1 51706
Co-fractionation Homo sapiens
4 RAF1 5894
Affinity Capture-MS Homo sapiens
5 BNIP3L  
Affinity Capture-MS Homo sapiens
6 HSD17B4 3295
Co-fractionation Homo sapiens
7 PTF1A  
Two-hybrid Homo sapiens
8 C21orf2  
Affinity Capture-MS Homo sapiens
9 PRDX3 10935
Co-fractionation Homo sapiens
10 HSPB1 3315
Two-hybrid Homo sapiens
11 CCNYL1 151195
Affinity Capture-MS Homo sapiens
12 NUDT22  
Affinity Capture-MS Homo sapiens
13 DCUN1D3 123879
Affinity Capture-MS Homo sapiens
14 RPGRIP1L 23322
Affinity Capture-MS Homo sapiens
15 PIPSL 266971
Affinity Capture-MS Homo sapiens
16 C1orf21  
Affinity Capture-MS Homo sapiens
17 EEPD1 80820
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SPATA7 is involved
No pathways found





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