Gene description for Samhd1
Gene name	SAM domain and HD domain, 1
Gene symbol	Samhd1
Other names/aliases	E330031J07Rik Mg11
Species	Mus musculus
Database cross references - Samhd1
ExoCarta	ExoCarta_56045
Vesiclepedia	VP_56045
Entrez Gene	56045
UniProt	Q60710
Samhd1 identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Samhd1

Molecular Function     nucleic acid binding GO:0003676 ISO     nucleic acid binding GO:0003676 ISS     single-stranded DNA binding GO:0003697 ISO     single-stranded DNA binding GO:0003697 ISS     RNA binding GO:0003723 ISO     RNA binding GO:0003723 ISS     RNA nuclease activity GO:0004540 ISO     RNA nuclease activity GO:0004540 ISS     GTP binding GO:0005525 IEA     zinc ion binding GO:0008270 ISO     zinc ion binding GO:0008270 ISS     dGTPase activity GO:0008832 IBA     dGTPase activity GO:0008832 IDA     dGTPase activity GO:0008832 ISO     triphosphoric monoester hydrolase activity GO:0016793 IDA     triphosphoric monoester hydrolase activity GO:0016793 ISO     dGTP binding GO:0032567 ISO     dGTP binding GO:0032567 ISS     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO     deoxynucleoside triphosphate hydrolase activity GO:0106375 IEA Biological Process     double-strand break repair via homologous recombination GO:0000724 ISO     double-strand break repair via homologous recombination GO:0000724 ISS     dGTP catabolic process GO:0006203 IBA     dGTP catabolic process GO:0006203 ISO     dGTP catabolic process GO:0006203 ISS     DNA damage response GO:0006974 ISO     DNA damage response GO:0006974 ISS     deoxyribonucleotide catabolic process GO:0009264 ISO     deoxyribonucleotide catabolic process GO:0009264 ISS     somatic hypermutation of immunoglobulin genes GO:0016446 IMP     innate immune response GO:0045087 IEA     regulation of innate immune response GO:0045088 IBA     regulation of innate immune response GO:0045088 ISO     regulation of innate immune response GO:0045088 ISS     dATP catabolic process GO:0046061 ISO     dATP catabolic process GO:0046061 ISS     protein homotetramerization GO:0051289 IDA     protein homotetramerization GO:0051289 ISO     defense response to virus GO:0051607 IBA     defense response to virus GO:0051607 IMP     defense response to virus GO:0051607 ISO     negative regulation of type I interferon-mediated signaling pathway GO:0060339 IMP     negative regulation of type I interferon-mediated signaling pathway GO:0060339 ISO     DNA strand resection involved in replication fork processing GO:0110025 ISO     DNA strand resection involved in replication fork processing GO:0110025 ISS Subcellular Localization     nucleus GO:0005634 IBA     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     plasma membrane GO:0005886 ISO     site of double-strand break GO:0035861 ISO     site of double-strand break GO:0035861 ISS     tetraspanin-enriched microdomain GO:0097197 IEA     tetraspanin-enriched microdomain GO:0097197 ISO