Gene description for KLK7
Gene name kallikrein-related peptidase 7
Gene symbol KLK7
Other names/aliases PRSS6
SCCE
hK7
Species Homo sapiens
 Database cross references - KLK7
ExoCarta ExoCarta_5650
Vesiclepedia VP_5650
Entrez Gene 5650
HGNC 6368
MIM 604438
UniProt P49862  
 KLK7 identified in sEVs derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
 Gene ontology annotations for KLK7
Molecular Function
    metalloendopeptidase activity GO:0004222 TAS
    serine-type endopeptidase activity GO:0004252 IBA
    peptidase activity GO:0008233 IMP
    serine-type peptidase activity GO:0008236 TAS
Biological Process
    positive regulation of antibacterial peptide production GO:0002803 IMP
    proteolysis GO:0006508 IEA
    epidermis development GO:0008544 TAS
    extracellular matrix disassembly GO:0022617 TAS
    protein maturation GO:0051604 IBA
Subcellular Localization
    cornified envelope GO:0001533 IEA
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IMP
    secretory granule GO:0030141 IBA
    epidermal lamellar body GO:0097209 IDA
 Experiment description of studies that identified KLK7 in sEVs
1
Experiment ID 189
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
MISEV standards
EM
Biophysical techniques
HSC70
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KLK7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRSS16 10279
Affinity Capture-MS Homo sapiens
2 TNFAIP3 7128
Affinity Capture-MS Homo sapiens
3 EPHX4 253152
Affinity Capture-MS Homo sapiens
4 IFNA4  
Affinity Capture-MS Homo sapiens
5 DTL  
Affinity Capture-MS Homo sapiens
6 ST8SIA1  
Affinity Capture-MS Homo sapiens
7 VNN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ADSS 159
Affinity Capture-MS Homo sapiens
9 SLC25A6 293
Affinity Capture-MS Homo sapiens
10 C18orf21  
Affinity Capture-MS Homo sapiens
11 FANCD2  
Affinity Capture-MS Homo sapiens
12 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
13 CCNC  
Affinity Capture-MS Homo sapiens
14 SCGB1D1  
Affinity Capture-MS Homo sapiens
15 FCF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 RPS19BP1  
Affinity Capture-MS Homo sapiens
17 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 TRIM41 90933
Affinity Capture-MS Homo sapiens
19 VAV1 7409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 PHF8  
Affinity Capture-MS Homo sapiens
21 MTAP 4507
Affinity Capture-MS Homo sapiens
22 UBE3A 7337
Affinity Capture-MS Homo sapiens
23 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 C1orf35  
Affinity Capture-MS Homo sapiens
25 ZC3HC1  
Affinity Capture-MS Homo sapiens
26 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
27 ZNF154  
Affinity Capture-MS Homo sapiens
28 PTDSS1 9791
Affinity Capture-MS Homo sapiens
29 SFR1 119392
Affinity Capture-MS Homo sapiens
30 PLK2  
Affinity Capture-MS Homo sapiens
31 FTH1 2495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 MYCBPAP 84073
Affinity Capture-MS Homo sapiens
33 ZIC1  
Affinity Capture-MS Homo sapiens
34 APP 351
Reconstituted Complex Homo sapiens
35 PI4KA 5297
Affinity Capture-MS Homo sapiens
36 KLHL11  
Affinity Capture-MS Homo sapiens
37 HEY2  
Affinity Capture-MS Homo sapiens
38 CHST10  
Affinity Capture-MS Homo sapiens
39 MBNL1 4154
Affinity Capture-MS Homo sapiens
40 UBAC2 337867
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 PCOLCE2 26577
Affinity Capture-MS Homo sapiens
42 KIR3DS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 PI4KAP1  
Affinity Capture-MS Homo sapiens
44 CDSN 1041
Biochemical Activity Homo sapiens
45 TOMM6  
Affinity Capture-MS Homo sapiens
46 LRRC10  
Affinity Capture-MS Homo sapiens
47 PIGT 51604
Affinity Capture-MS Homo sapiens
48 PINK1  
Affinity Capture-MS Homo sapiens
49 CA8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 TOX4  
Affinity Capture-MS Homo sapiens
51 ALDH3A1 218
Affinity Capture-MS Homo sapiens
52 E2F6 1876
Affinity Capture-MS Homo sapiens
53 SSUH2  
Affinity Capture-MS Homo sapiens
54 UBE2J2 118424
Affinity Capture-MS Homo sapiens
55 PLCZ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 ZDHHC19  
Affinity Capture-MS Homo sapiens
57 GMCL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 GABPA 2551
Affinity Capture-MS Homo sapiens
59 CCR1  
Affinity Capture-MS Homo sapiens
60 STX17 55014
Affinity Capture-MS Homo sapiens
61 GALNT9  
Affinity Capture-MS Homo sapiens
62 EHBP1 23301
Affinity Capture-MS Homo sapiens
63 APIP 51074
Affinity Capture-MS Homo sapiens
64 PHF11 51131
Affinity Capture-MS Homo sapiens
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