Gene description for NLGN2
Gene name neuroligin 2
Gene symbol NLGN2
Other names/aliases -
Species Homo sapiens
 Database cross references - NLGN2
ExoCarta ExoCarta_57555
Vesiclepedia VP_57555
Entrez Gene 57555
HGNC 14290
MIM 606479
UniProt Q8NFZ4  
 NLGN2 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for NLGN2
Molecular Function
    neurexin family protein binding GO:0042043 ISS
    neurexin family protein binding GO:0042043 NAS
    identical protein binding GO:0042802 IEA
    cell adhesion molecule binding GO:0050839 ISS
Biological Process
    thigmotaxis GO:0001966 IEA
    regulation of respiratory gaseous exchange by nervous system process GO:0002087 ISS
    neuron cell-cell adhesion GO:0007158 ISS
    synapse assembly GO:0007416 ISS
    synapse assembly GO:0007416 NAS
    jump response GO:0007630 IEA
    positive regulation of cell population proliferation GO:0008284 IEA
    sensory perception of pain GO:0019233 IEA
    positive regulation of insulin secretion GO:0032024 IMP
    positive regulation of synaptic transmission, GABAergic GO:0032230 ISS
    protein localization to cell surface GO:0034394 IEA
    social behavior GO:0035176 IEA
    protein localization to synapse GO:0035418 ISS
    locomotory exploration behavior GO:0035641 IEA
    cell-cell junction maintenance GO:0045217 NAS
    modulation of chemical synaptic transmission GO:0050804 ISS
    synapse organization GO:0050808 ISS
    neuromuscular process controlling balance GO:0050885 IEA
    synaptic transmission, GABAergic GO:0051932 IEA
    positive regulation of synapse assembly GO:0051965 ISS
    positive regulation of synaptic transmission, glutamatergic GO:0051968 ISS
    positive regulation of dendritic spine development GO:0060999 IEA
    terminal button organization GO:0072553 ISS
    neurotransmitter-gated ion channel clustering GO:0072578 IEA
    postsynaptic membrane assembly GO:0097104 ISS
    presynaptic membrane assembly GO:0097105 ISS
    gephyrin clustering involved in postsynaptic density assembly GO:0097116 ISS
    postsynaptic density protein 95 clustering GO:0097119 ISS
    positive regulation of inhibitory postsynaptic potential GO:0097151 ISS
    cell-cell adhesion GO:0098609 NAS
    presynapse assembly GO:0099054 TAS
    insulin metabolic process GO:1901142 IEA
    positive regulation of protein localization to synapse GO:1902474 IDA
    positive regulation of t-SNARE clustering GO:1904034 IEA
    inhibitory synapse assembly GO:1904862 IEA
    regulation of presynapse assembly GO:1905606 IEA
    regulation of AMPA receptor activity GO:2000311 ISS
    positive regulation of excitatory postsynaptic potential GO:2000463 ISS
    positive regulation of synaptic vesicle clustering GO:2000809 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 ISS
    membrane GO:0016020 NAS
    membrane GO:0016020 TAS
    axon GO:0030424 IEA
    presynaptic membrane GO:0042734 IEA
    dendritic shaft GO:0043198 IEA
    synapse GO:0045202 ISS
    postsynaptic membrane GO:0045211 ISS
    postsynaptic membrane GO:0045211 NAS
    excitatory synapse GO:0060076 IEA
    inhibitory synapse GO:0060077 ISS
    ribbon synapse GO:0097470 IEA
    glycinergic synapse GO:0098690 IEA
    dopaminergic synapse GO:0098691 IEA
    symmetric, GABA-ergic, inhibitory synapse GO:0098983 TAS
    postsynaptic specialization membrane GO:0099634 IBA
 Experiment description of studies that identified NLGN2 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NLGN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYZL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 UPK2 7379
Affinity Capture-MS Homo sapiens
3 HTR3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 GPIHBP1  
Affinity Capture-MS Homo sapiens
5 PRTN3 5657
Affinity Capture-MS Homo sapiens
6 SNX27 81609
Affinity Capture-MS Homo sapiens
7 BTNL2  
Affinity Capture-MS Homo sapiens
8 TMEM106A  
Affinity Capture-MS Homo sapiens
9 NAAA  
Affinity Capture-MS Homo sapiens
10 UGT1A7 54577
Affinity Capture-MS Homo sapiens
11 TTC5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 HLA-G 3135
Affinity Capture-MS Homo sapiens
13 NRXN3 9369
Reconstituted Complex Homo sapiens
14 DLG3 1741
Two-hybrid Homo sapiens
15 ADCY9 115
Affinity Capture-MS Homo sapiens
16 NLGN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 NRXN2  
Reconstituted Complex Homo sapiens
18 PDGFRA 5156
Affinity Capture-MS Homo sapiens
19 RYK 6259
Affinity Capture-MS Homo sapiens
20 HS2ST1 9653
Affinity Capture-MS Homo sapiens
21 ECEL1  
Affinity Capture-MS Homo sapiens
22 RLN1  
Affinity Capture-MS Homo sapiens
23 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
24 CD1B 910
Affinity Capture-MS Homo sapiens
25 DLG4  
Two-hybrid Homo sapiens
26 CLU 1191
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
28 TNFSF18 8995
Affinity Capture-MS Homo sapiens
29 SFTPC  
Affinity Capture-MS Homo sapiens
30 GZMH  
Affinity Capture-MS Homo sapiens
31 TAZ  
Affinity Capture-MS Homo sapiens
32 DKKL1  
Affinity Capture-MS Homo sapiens
33 NRXN1  
Reconstituted Complex Homo sapiens
34 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
35 B3GAT1  
Proximity Label-MS Homo sapiens
36 C1QB 713
Affinity Capture-MS Homo sapiens
37 IDS  
Affinity Capture-MS Homo sapiens
38 SUSD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 CST11  
Affinity Capture-MS Homo sapiens
40 CRISP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 DEFB135  
Affinity Capture-MS Homo sapiens
42 DNAJB9 4189
Affinity Capture-MS Homo sapiens
43 B3GAT2  
Affinity Capture-MS Homo sapiens
44 CDHR4  
Affinity Capture-MS Homo sapiens
45 ASIC4  
Affinity Capture-MS Homo sapiens
46 DHFRL1  
Affinity Capture-MS Homo sapiens
47 B3GAT3 26229
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 PATE1  
Affinity Capture-MS Homo sapiens
49 FAM19A2 338811
Affinity Capture-MS Homo sapiens
50 KLRC1  
Affinity Capture-MS Homo sapiens
51 ST8SIA5  
Affinity Capture-MS Homo sapiens
52 CFC1  
Affinity Capture-MS Homo sapiens
53 ST8SIA4 7903
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 SEMA4B  
Affinity Capture-MS Homo sapiens
55 DLG2 1740
Two-hybrid Homo sapiens
56 HLA-C 3107
Affinity Capture-MS Homo sapiens
57 NMS  
Affinity Capture-MS Homo sapiens
58 MAN1A1 4121
Affinity Capture-MS Homo sapiens
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