Gene description for DLG2
Gene name discs, large homolog 2 (Drosophila)
Gene symbol DLG2
Other names/aliases PPP1R58
PSD-93
PSD93
chapsyn-110
Species Homo sapiens
 Database cross references - DLG2
ExoCarta ExoCarta_1740
Vesiclepedia VP_1740
Entrez Gene 1740
HGNC 2901
MIM 603583
UniProt Q15700  
 DLG2 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for DLG2
Molecular Function
    guanylate kinase activity GO:0004385 TAS
    protein binding GO:0005515 IPI
    kinase binding GO:0019900 IDA
    protein kinase binding GO:0019901 IBA
    ionotropic glutamate receptor binding GO:0035255 IBA
Biological Process
    chemical synaptic transmission GO:0007268 IBA
    nervous system development GO:0007399 IBA
    protein localization to synapse GO:0035418 IBA
    cellular response to potassium ion GO:0035865 ISS
    receptor clustering GO:0043113 IBA
    establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 IBA
    establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 NAS
    GMP metabolic process GO:0046037 IEA
    GDP metabolic process GO:0046710 IEA
    receptor localization to synapse GO:0097120 IBA
    cell-cell adhesion GO:0098609 IBA
    regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072 IBA
    anterograde axonal protein transport GO:0099641 ISS
    retrograde axonal protein transport GO:0099642 ISS
Subcellular Localization
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 TAS
    adherens junction GO:0005912 NAS
    voltage-gated potassium channel complex GO:0008076 ISS
    postsynaptic density GO:0014069 ISS
    membrane GO:0016020 ISS
    basolateral plasma membrane GO:0016323 IBA
    neuromuscular junction GO:0031594 IBA
    neuron projection GO:0043005 IBA
    perikaryon GO:0043204 IEA
    juxtaparanode region of axon GO:0044224 ISS
    postsynaptic density membrane GO:0098839 IBA
    axon cytoplasm GO:1904115 IEA
 Experiment description of studies that identified DLG2 in sEVs
1
Experiment ID 224
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for DLG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KDELR1 10945
Two-hybrid Homo sapiens
2 KCNA4  
Affinity Capture-Western Homo sapiens
3 DLGAP2  
Two-hybrid Homo sapiens
4 PRNP 5621
Affinity Capture-MS Homo sapiens
5 DLG3 1741
Affinity Capture-MS Homo sapiens
6 RNASE2 6036
Two-hybrid Homo sapiens
7 VTN 7448
Two-hybrid Homo sapiens
8 FA2H  
Two-hybrid Homo sapiens
9 DLGAP1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
10 NLGN3  
Two-hybrid Homo sapiens
11 GUCY1A2  
Affinity Capture-Western Homo sapiens
12 FASLG 356
Protein-peptide Homo sapiens
13 ERBB4 2066
Two-hybrid Homo sapiens
14 PLEKHA2 59339
Two-hybrid Homo sapiens
15 DLG4  
Affinity Capture-Western Homo sapiens
16 RPF2 84154
Two-hybrid Homo sapiens
17 PPIL4  
Two-hybrid Homo sapiens
18 PSMD14 10213
Affinity Capture-MS Homo sapiens
19 DLGAP3  
Two-hybrid Homo sapiens
20 TFAM 7019
Cross-Linking-MS (XL-MS) Homo sapiens
21 GRIN2B  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
22 KCNJ4  
Affinity Capture-Western Homo sapiens
23 ATP2B2 491
Affinity Capture-Western Homo sapiens
24 LRP2 4036
Two-hybrid Homo sapiens
25 RPS8 6202
Two-hybrid Homo sapiens
26 NLGN1  
Two-hybrid Homo sapiens
27 MCAM 4162
Proximity Label-MS Homo sapiens
28 KRAS 3845
Synthetic Lethality Homo sapiens
29 MAP1A 4130
Affinity Capture-Western Homo sapiens
30 KHDRBS1 10657
Protein-peptide Homo sapiens
31 GRIN2A  
Two-hybrid Homo sapiens
32 DYNLL2 140735
Affinity Capture-Western Homo sapiens
33 ATP2B4 493
Affinity Capture-Western Homo sapiens
34 SEMA4C 54910
Two-hybrid Homo sapiens
35 KCNJ12 3768
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
36 SERPINB13 5275
Two-hybrid Homo sapiens
37 DYNLL1 8655
Affinity Capture-Western Homo sapiens
38 NLGN2 57555
Two-hybrid Homo sapiens
39 NOS1  
Two-hybrid Homo sapiens
40 AOAH  
Two-hybrid Homo sapiens
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