Gene description for MAP1A
Gene name microtubule-associated protein 1A
Gene symbol MAP1A
Other names/aliases MAP1L
MTAP1A
Species Homo sapiens
 Database cross references - MAP1A
ExoCarta ExoCarta_4130
Vesiclepedia VP_4130
Entrez Gene 4130
HGNC 6835
MIM 600178
UniProt P78559  
 MAP1A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocytes 26054723    
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
 Gene ontology annotations for MAP1A
Molecular Function
    actin binding GO:0003779 IBA
    actin binding GO:0003779 ISS
    structural molecule activity GO:0005198 NAS
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IBA
    microtubule binding GO:0008017 ISS
    microtubule binding GO:0008017 TAS
    cytoskeletal anchor activity GO:0008093 ISS
    tubulin binding GO:0015631 ISS
    tau protein binding GO:0048156 NAS
Biological Process
    microtubule cytoskeleton organization GO:0000226 IBA
    microtubule cytoskeleton organization GO:0000226 ISS
    axonogenesis GO:0007409 IBA
    memory GO:0007613 ISS
    associative learning GO:0008306 ISS
    dendrite development GO:0016358 IBA
    regulation of microtubule depolymerization GO:0031114 IBA
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 ISS
    regulation of synaptic plasticity GO:0048167 ISS
    voluntary musculoskeletal movement GO:0050882 ISS
    neuron cellular homeostasis GO:0070050 ISS
    anterograde axonal protein transport GO:0099641 ISS
    retrograde axonal protein transport GO:0099642 ISS
    negative regulation of protein localization to microtubule GO:1902817 ISS
    positive regulation of protein localization GO:1903829 ISS
    neuron projection maintenance GO:1990535 ISS
    positive regulation of protein localization to cell surface GO:2000010 ISS
Subcellular Localization
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IBA
    microtubule GO:0005874 IBA
    microtubule associated complex GO:0005875 IBA
    axon GO:0030424 ISS
    dendrite GO:0030425 IBA
    dendrite GO:0030425 ISS
    neuron projection GO:0043005 ISS
    neuronal cell body GO:0043025 IBA
    neuronal cell body GO:0043025 ISS
    axon initial segment GO:0043194 ISS
    dendritic shaft GO:0043198 ISS
    dendritic branch GO:0044307 ISS
    synapse GO:0045202 IBA
    primary dendrite GO:0150001 ISS
    dendritic microtubule GO:1901588 ISS
    axon cytoplasm GO:1904115 IEA
 Experiment description of studies that identified MAP1A in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
6
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
7
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MAP1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNL2 29889
Affinity Capture-MS Homo sapiens
2 TRAPPC6B 122553
Affinity Capture-MS Homo sapiens
3 GPM6A 2823
Affinity Capture-MS Homo sapiens
4 ABCF3 55324
Affinity Capture-MS Homo sapiens
5 DISC1 27185
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
6 FAM153C  
Affinity Capture-MS Homo sapiens
7 KIF2A 3796
Proximity Label-MS Homo sapiens
8 OGT 8473
Reconstituted Complex Homo sapiens
9 FAM153B  
Affinity Capture-MS Homo sapiens
10 PFN1 5216
Proximity Label-MS Homo sapiens
11 DIDO1  
Affinity Capture-MS Homo sapiens
12 SLU7  
Affinity Capture-MS Homo sapiens
13 GRB2 2885
Two-hybrid Homo sapiens
14 FEN1 2237
Cross-Linking-MS (XL-MS) Homo sapiens
15 CAPN10  
Affinity Capture-MS Homo sapiens
16 MDH2 4191
Cross-Linking-MS (XL-MS) Homo sapiens
17 SPP1 6696
Two-hybrid Homo sapiens
18 BAG5 9529
Affinity Capture-MS Homo sapiens
19 TRAF3IP1 26146
Affinity Capture-MS Homo sapiens
20 DLG1 1739
Affinity Capture-Western Homo sapiens
21 SOX2  
Affinity Capture-MS Homo sapiens
22 TAS2R31  
Affinity Capture-MS Homo sapiens
23 MECP2 4204
Affinity Capture-MS Homo sapiens
24 HSPA1A 3303
Affinity Capture-MS Homo sapiens
25 PRKAG2 51422
Affinity Capture-MS Homo sapiens
26 MAPRE3  
Proximity Label-MS Homo sapiens
27 DLG4  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
28 Mib1  
Two-hybrid Mus musculus
29 GGA2 23062
Affinity Capture-MS Homo sapiens
30 LINC00346  
Affinity Capture-MS Homo sapiens
31 CCDC71  
Affinity Capture-MS Homo sapiens
32 IFIT1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 FTSJ3 117246
Affinity Capture-MS Homo sapiens
34 MAP1LC3B 81631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 TRIM37  
Proximity Label-MS Homo sapiens
36 LOC338797  
Affinity Capture-MS Homo sapiens
37 MAP1LC3A 84557
Affinity Capture-MS Homo sapiens
38 SPCS1 28972
Affinity Capture-MS Homo sapiens
39 GRIN2B  
Affinity Capture-Western Homo sapiens
40 SREK1IP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 NTRK1 4914
Affinity Capture-MS Homo sapiens
42 GARS 2617
Affinity Capture-MS Homo sapiens
43 TP63  
Affinity Capture-MS Homo sapiens
44 KLK12  
Affinity Capture-MS Homo sapiens
45 NUFIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 DCTN1 1639
Proximity Label-MS Homo sapiens
47 BRD1 23774
Affinity Capture-MS Homo sapiens
48 AKR7L 246181
Affinity Capture-MS Homo sapiens
49 AP1G1 164
Affinity Capture-MS Homo sapiens
50 CUL7 9820
Affinity Capture-MS Homo sapiens
51 RHOB 388
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
52 OR13C3  
Affinity Capture-MS Homo sapiens
53 INSIG1  
Affinity Capture-MS Homo sapiens
54 ATOH1  
Affinity Capture-MS Homo sapiens
55 ARAF 369
Affinity Capture-MS Homo sapiens
56 UPF2 26019
Two-hybrid Homo sapiens
57 GGA1 26088
Affinity Capture-MS Homo sapiens
58 KIAA0408  
Affinity Capture-MS Homo sapiens
59 ALS2CR11  
Affinity Capture-MS Homo sapiens
60 DDX55  
Affinity Capture-MS Homo sapiens
61 DLG2 1740
Affinity Capture-Western Homo sapiens
62 ZBTB44  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MAP1A is involved
No pathways found





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