Gene description for DPP10
Gene name dipeptidyl-peptidase 10 (non-functional)
Gene symbol DPP10
Other names/aliases DPL2
DPPY
DPRP-3
DPRP3
Species Homo sapiens
 Database cross references - DPP10
ExoCarta ExoCarta_57628
Vesiclepedia VP_57628
Entrez Gene 57628
HGNC 20823
MIM 608209
UniProt Q8N608  
 DPP10 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for DPP10
Molecular Function
    serine-type peptidase activity GO:0008236 IEA
    dipeptidyl-peptidase activity GO:0008239 IDA
    potassium channel regulator activity GO:0015459 IBA
    potassium channel regulator activity GO:0015459 ISS
    transmembrane transporter binding GO:0044325 IPI
Biological Process
    proteolysis GO:0006508 IEA
    protein localization to plasma membrane GO:0072659 ISS
    regulation of potassium ion transmembrane transport GO:1901379 IBA
    regulation of potassium ion transmembrane transport GO:1901379 ISS
    positive regulation of protein localization to plasma membrane GO:1903078 IDA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISS
    voltage-gated potassium channel complex GO:0008076 IBA
    voltage-gated potassium channel complex GO:0008076 IPI
    membrane GO:0016020 IDA
 Experiment description of studies that identified DPP10 in sEVs
1
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for DPP10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BAG3 9531
Affinity Capture-Luminescence Homo sapiens
2 DPP10 57628
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 KCND2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
4 KCND3 3752
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which DPP10 is involved
No pathways found





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