Gene description for RDH5
Gene name retinol dehydrogenase 5 (11-cis/9-cis)
Gene symbol RDH5
Other names/aliases 9cRDH
HSD17B9
RDH1
SDR9C5
Species Homo sapiens
 Database cross references - RDH5
ExoCarta ExoCarta_5959
Vesiclepedia VP_5959
Entrez Gene 5959
HGNC 9940
MIM 601617
UniProt Q92781  
 RDH5 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for RDH5
Molecular Function
    all-trans-retinol dehydrogenase (NAD+) activity GO:0004745 IBA
    all-trans-retinol dehydrogenase (NAD+) activity GO:0004745 IDA
    all-trans-retinol dehydrogenase (NAD+) activity GO:0004745 TAS
    protein homodimerization activity GO:0042803 IDA
    androsterone dehydrogenase activity GO:0047023 IDA
    androstan-3-alpha,17-beta-diol dehydrogenase activity GO:0047044 IDA
    11-cis-retinol dehydrogenase GO:0106429 IEA
Biological Process
    retinoid metabolic process GO:0001523 IBA
    retinoid metabolic process GO:0001523 IDA
    retinoid metabolic process GO:0001523 TAS
    visual perception GO:0007601 IEA
    steroid metabolic process GO:0008202 IBA
    steroid metabolic process GO:0008202 IDA
    retinol metabolic process GO:0042572 IEA
Subcellular Localization
    endoplasmic reticulum lumen GO:0005788 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    intracellular membrane-bounded organelle GO:0043231 IBA
    cell body GO:0044297 IEA
 Experiment description of studies that identified RDH5 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for RDH5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NME2P1 283458
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 DDI2 84301
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 RLBP1  
Reconstituted Complex Homo sapiens
4 UBE2G1 7326
Affinity Capture-MS Homo sapiens
5 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
6 GNPNAT1 64841
Affinity Capture-MS Homo sapiens
7 HERC3 8916
Affinity Capture-MS Homo sapiens
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