Gene description for RYR1
Gene name	ryanodine receptor 1 (skeletal)
Gene symbol	RYR1
Other names/aliases	CCO MHS MHS1 PPP1R137 RYDR RYR RYR-1 SKRR
Species	Homo sapiens
Database cross references - RYR1
ExoCarta	ExoCarta_6261
Vesiclepedia	VP_6261
Entrez Gene	6261
HGNC	10483
MIM	180901
UniProt	P21817
RYR1 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Prostate cancer cells	25844599
Urine	19056867

Gene ontology annotations for RYR1

Molecular Function     ryanodine-sensitive calcium-release channel activity GO:0005219 IBA     ryanodine-sensitive calcium-release channel activity GO:0005219 IDA     ryanodine-sensitive calcium-release channel activity GO:0005219 IMP     ryanodine-sensitive calcium-release channel activity GO:0005219 ISS     ryanodine-sensitive calcium-release channel activity GO:0005219 TAS     voltage-gated calcium channel activity GO:0005245 ISS     calcium channel activity GO:0005262 ISS     calcium ion binding GO:0005509 ISS     calmodulin binding GO:0005516 ISS     ATP binding GO:0005524 ISS     intracellularly gated calcium channel activity GO:0015278 TAS     calcium-induced calcium release activity GO:0048763 IMP Biological Process     response to hypoxia GO:0001666 IDA     outflow tract morphogenesis GO:0003151 ISS     calcium ion transport GO:0006816 ISS     muscle contraction GO:0006936 ISS     striated muscle contraction GO:0006941 IBA     release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 IBA     release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 ISS     calcium-mediated signaling GO:0019722 IEA     response to caffeine GO:0031000 ISS     skin development GO:0043588 ISS     ossification involved in bone maturation GO:0043931 ISS     skeletal muscle fiber development GO:0048741 ISS     release of sequestered calcium ion into cytosol GO:0051209 IDA     release of sequestered calcium ion into cytosol GO:0051209 IMP     release of sequestered calcium ion into cytosol GO:0051209 ISS     protein homotetramerization GO:0051289 ISS     regulation of cytosolic calcium ion concentration GO:0051480 ISS     cellular response to calcium ion GO:0071277 ISS     cellular response to caffeine GO:0071313 IMP     cellular response to caffeine GO:0071313 ISS Subcellular Localization     cytoplasm GO:0005737 IDA     smooth endoplasmic reticulum GO:0005790 IBA     plasma membrane GO:0005886 IDA     cell cortex GO:0005938 IDA     junctional sarcoplasmic reticulum membrane GO:0014701 TAS     terminal cisterna GO:0014802 ISS     sarcoplasmic reticulum GO:0016529 ISS     Z disc GO:0030018 IBA     organelle membrane GO:0031090 ISS     I band GO:0031674 IDA     sarcoplasmic reticulum membrane GO:0033017 IBA     sarcoplasmic reticulum membrane GO:0033017 IDA     sarcoplasmic reticulum membrane GO:0033017 ISS     sarcoplasmic reticulum membrane GO:0033017 TAS     calcium channel complex GO:0034704 IBA     sarcolemma GO:0042383 IBA     extracellular exosome GO:0070062 HDA     ryanodine receptor complex GO:1990425 ISS