Gene description for CCL7
Gene name chemokine (C-C motif) ligand 7
Gene symbol CCL7
Other names/aliases FIC
MARC
MCP-3
MCP3
NC28
SCYA6
SCYA7
Species Homo sapiens
 Database cross references - CCL7
ExoCarta ExoCarta_6354
Vesiclepedia VP_6354
Entrez Gene 6354
HGNC 10634
MIM 158106
UniProt P80098  
 CCL7 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CCL7
Molecular Function
    protein binding GO:0005515 IPI
    chemokine activity GO:0008009 IBA
    chemokine activity GO:0008009 IDA
    heparin binding GO:0008201 IEA
    CCR1 chemokine receptor binding GO:0031726 IPI
    CCR2 chemokine receptor binding GO:0031727 IEA
    CCR chemokine receptor binding GO:0048020 IBA
Biological Process
    monocyte chemotaxis GO:0002548 IC
    intracellular calcium ion homeostasis GO:0006874 TAS
    chemotaxis GO:0006935 TAS
    inflammatory response GO:0006954 IBA
    cytoskeleton organization GO:0007010 IDA
    signal transduction GO:0007165 TAS
    cell-cell signaling GO:0007267 TAS
    regulation of cell shape GO:0008360 IDA
    response to gamma radiation GO:0010332 IEA
    positive regulation of cell migration GO:0030335 IBA
    positive regulation of cell migration GO:0030335 IDA
    eosinophil chemotaxis GO:0048245 IBA
    eosinophil chemotaxis GO:0048245 IDA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IBA
    chemokine-mediated signaling pathway GO:0070098 IBA
    cellular response to ethanol GO:0071361 IEA
    positive regulation of natural killer cell chemotaxis GO:2000503 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified CCL7 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CCL7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MMP2 4313
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
2 UBQLN2 29978
Two-hybrid Homo sapiens
3 FEZ1  
Two-hybrid Homo sapiens
4 C12orf49  
Positive Genetic Homo sapiens
5 CCR3  
Reconstituted Complex Homo sapiens
6 CCR1  
Reconstituted Complex Homo sapiens
7 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
8 UBQLN1 29979
Two-hybrid Homo sapiens
9 CXCL6  
Reconstituted Complex Homo sapiens
10 XCL2  
Reconstituted Complex Homo sapiens
11 ACKR2  
Reconstituted Complex Homo sapiens
12 CCL7 6354
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
View the network image/svg+xml



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