Gene description for CCL22
Gene name chemokine (C-C motif) ligand 22
Gene symbol CCL22
Other names/aliases A-152E5.1
ABCD-1
DC/B-CK
MDC
SCYA22
STCP-1
Species Homo sapiens
 Database cross references - CCL22
ExoCarta ExoCarta_6367
Vesiclepedia VP_6367
Entrez Gene 6367
HGNC 10621
MIM 602957
UniProt O00626  
 CCL22 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for CCL22
Molecular Function
    protein binding GO:0005515 IPI
    chemokine activity GO:0008009 IBA
    CCR chemokine receptor binding GO:0048020 IBA
Biological Process
    chemotaxis GO:0006935 TAS
    inflammatory response GO:0006954 IBA
    immune response GO:0006955 TAS
    signal transduction GO:0007165 TAS
    cell-cell signaling GO:0007267 TAS
    response to virus GO:0009615 TAS
    positive regulation of cell migration GO:0030335 IBA
    killing of cells of another organism GO:0031640 IDA
    eosinophil chemotaxis GO:0048245 IBA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IBA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IDA
    chemokine-mediated signaling pathway GO:0070098 IBA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified CCL22 in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for CCL22
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VCAM1 7412
Reconstituted Complex Homo sapiens
2 GLS 2744
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CCL14  
Reconstituted Complex Homo sapiens
4 PDIA5 10954
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 EEF1A1 1915
Affinity Capture-MS Homo sapiens
6 PITRM1 10531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 HSPA12A 259217
Affinity Capture-MS Homo sapiens
8 YTHDF1 54915
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 LONRF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 DDX19B 11269
Affinity Capture-MS Homo sapiens
11 DSTYK 25778
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CCR4 1233
Reconstituted Complex Homo sapiens
13 CRYAB 1410
Two-hybrid Homo sapiens
14 DPP8 54878
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 EME1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 PF4V1 5197
Reconstituted Complex Homo sapiens
17 TUBB3 10381
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 TAB1 10454
Affinity Capture-MS Homo sapiens
19 SEPHS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 CHD1L 9557
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 PRUNE 58497
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 KDM4A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 DPP4 1803
Biochemical Activity Homo sapiens
24 RAD51D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 LNPEP 4012
Affinity Capture-MS Homo sapiens
26 TSEN2  
Affinity Capture-MS Homo sapiens
27 FAM118B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 CNTNAP3B  
Affinity Capture-MS Homo sapiens
29 ITPA 3704
Affinity Capture-MS Homo sapiens
30 HERC3 8916
Two-hybrid Homo sapiens
31 MET 4233
Affinity Capture-MS Homo sapiens
32 CD109 135228
Affinity Capture-MS Homo sapiens
33 FGFR4 2264
Affinity Capture-MS Homo sapiens
34 OAF 220323
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 PLXNA2 5362
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 GCLC 2729
Two-hybrid Homo sapiens
37 CBWD1 55871
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 PPM1A 5494
Affinity Capture-MS Homo sapiens
39 ITGA8 8516
Affinity Capture-MS Homo sapiens
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