Gene description for PCIF1
Gene name PDX1 C-terminal inhibiting factor 1
Gene symbol PCIF1
Other names/aliases C20orf67
PPP1R121
Species Homo sapiens
 Database cross references - PCIF1
ExoCarta ExoCarta_63935
Vesiclepedia VP_63935
Entrez Gene 63935
HGNC 16200
UniProt Q9H4Z3  
 PCIF1 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PCIF1
Molecular Function
    mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity GO:0016422 IDA
    RNA polymerase II C-terminal domain binding GO:0099122 IDA
    S-adenosyl-L-methionine binding GO:1904047 IDA
    RNA polymerase II C-terminal domain phosphoserine binding GO:1990269 IDA
Biological Process
    mRNA processing GO:0006397 IDA
    regulation of translation GO:0006417 IDA
    negative regulation of translation GO:0017148 IDA
    methylation GO:0032259 IEA
    positive regulation of translation GO:0045727 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    microtubule cytoskeleton GO:0015630 IDA
    intercellular bridge GO:0045171 IDA
 Experiment description of studies that identified PCIF1 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PCIF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 POLR2C 5432
Proximity Label-MS Homo sapiens
3 FANCM 57697
Affinity Capture-MS Homo sapiens
4 S100A2 6273
Affinity Capture-MS Homo sapiens
5 ZCCHC6 79670
Affinity Capture-MS Homo sapiens
6 MNAT1  
Affinity Capture-MS Homo sapiens
7 S100P 6286
Affinity Capture-MS Homo sapiens
8 C19orf43  
Affinity Capture-MS Homo sapiens
9 NELFE 7936
Affinity Capture-MS Homo sapiens
10 POLR2I 5438
Affinity Capture-MS Homo sapiens
11 CAMSAP2  
Affinity Capture-MS Homo sapiens
12 PARP16 54956
Affinity Capture-MS Homo sapiens
13 PDX1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
14 HNRNPUL1 11100
Affinity Capture-MS Homo sapiens
15 POLR2A 5430
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PCIF1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here