Gene description for SEMA3F
Gene name sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
Gene symbol SEMA3F
Other names/aliases SEMA-IV
SEMA4
SEMAK
Species Homo sapiens
 Database cross references - SEMA3F
ExoCarta ExoCarta_6405
Vesiclepedia VP_6405
Entrez Gene 6405
HGNC 10728
MIM 601124
UniProt Q13275  
 SEMA3F identified in sEVs derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
 Gene ontology annotations for SEMA3F
Molecular Function
    semaphorin receptor binding GO:0030215 IBA
    neuropilin binding GO:0038191 IBA
    chemorepellent activity GO:0045499 IBA
    chemorepellent activity GO:0045499 IDA
Biological Process
    neural crest cell migration GO:0001755 IBA
    axon guidance GO:0007411 IBA
    axon guidance GO:0007411 IDA
    facial nerve structural organization GO:0021612 ISS
    trigeminal nerve structural organization GO:0021637 ISS
    nerve development GO:0021675 ISS
    branchiomotor neuron axon guidance GO:0021785 ISS
    positive regulation of cell migration GO:0030335 IBA
    ventral trunk neural crest cell migration GO:0036486 IEA
    negative regulation of axon extension involved in axon guidance GO:0048843 IEA
    axon extension involved in axon guidance GO:0048846 ISS
    negative chemotaxis GO:0050919 IBA
    sympathetic ganglion development GO:0061549 ISS
    semaphorin-plexin signaling pathway GO:0071526 IBA
    semaphorin-plexin signaling pathway GO:0071526 ISS
    sympathetic neuron projection extension GO:0097490 ISS
    sympathetic neuron projection guidance GO:0097491 ISS
    regulation of postsynapse organization GO:0099175 IEA
    neural crest cell migration involved in autonomic nervous system development GO:1901166 IEA
Subcellular Localization
    extracellular space GO:0005615 TAS
    plasma membrane GO:0005886 IBA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified SEMA3F in sEVs
1
Experiment ID 189
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
MISEV standards
✔
EM
Biophysical techniques
✔
HSC70
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SEMA3F
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NXF1 10482
Affinity Capture-RNA Homo sapiens
2 SEMA3C 10512
Affinity Capture-MS Homo sapiens
3 PDGFRA 5156
Affinity Capture-MS Homo sapiens
4 UBC 7316
Reconstituted Complex Homo sapiens
5 Nrp1 18186
Reconstituted Complex Mus musculus
6 MOV10 4343
Affinity Capture-RNA Homo sapiens
7 SHBG 6462
Two-hybrid Homo sapiens
8 NRP2 8828
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which SEMA3F is involved
No pathways found





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