Gene description for Uqcrfs1
Gene name ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
Gene symbol Uqcrfs1
Other names/aliases 4430402G14Rik
AI875505
Species Mus musculus
 Database cross references - Uqcrfs1
ExoCarta ExoCarta_66694
Vesiclepedia VP_66694
Entrez Gene 66694
UniProt Q9CR68  
 Uqcrfs1 identified in sEVs derived from the following tissue/cell type
Melanoma cells 34957415    
Melanoma cells 34957415    
 Gene ontology annotations for Uqcrfs1
Molecular Function
    protein binding GO:0005515 IPI
    ubiquinol-cytochrome-c reductase activity GO:0008121 IEA
    oxidoreductase activity GO:0016491 IBA
    protein-containing complex binding GO:0044877 IEA
    protein-containing complex binding GO:0044877 ISO
    metal ion binding GO:0046872 IEA
    2 iron, 2 sulfur cluster binding GO:0051537 IEA
Biological Process
    mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 IBA
    response to xenobiotic stimulus GO:0009410 IEA
    response to hormone GO:0009725 IEA
    respiratory electron transport chain GO:0022904 ISS
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 HDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial membrane GO:0031966 ISO
    myelin sheath GO:0043209 HDA
    respiratory chain complex III GO:0045275 IBA
    respiratory chain complex III GO:0045275 IDA
    respiratory chain complex III GO:0045275 ISO
    respiratory chain complex IV GO:0045277 ISO
 Experiment description of studies that identified Uqcrfs1 in sEVs
1
Experiment ID 1117
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 1118
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Uqcrfs1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Uqcrc1  
Co-fractionation Mus musculus
2 SNCA 6622
Affinity Capture-MS Homo sapiens
3 Cox6b1  
Co-fractionation Mus musculus
4 Pdha1  
Co-fractionation Mus musculus
5 Ndufb5  
Co-fractionation Mus musculus
6 Coq9  
Co-fractionation Mus musculus
7 Ndufc2  
Co-fractionation Mus musculus
8 Slc25a4 11739
Co-fractionation Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
9 Ckmt2  
Co-fractionation Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
10 Ndufa6  
Co-fractionation Mus musculus
11 Cisd1  
Co-fractionation Mus musculus
12 Cycs 13063
Co-fractionation Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
13 Ndufab1  
Co-fractionation Mus musculus
14 Uqcrh  
Co-fractionation Mus musculus
15 Atp5f1  
Co-fractionation Mus musculus
16 Atxn1  
Affinity Capture-MS Mus musculus
17 Immt  
Cross-Linking-MS (XL-MS) Mus musculus
18 Kctd13  
Affinity Capture-MS Mus musculus
19 Cox6c  
Co-fractionation Mus musculus
20 Atp5j  
Co-fractionation Mus musculus
21 Aco2 11429
Co-fractionation Mus musculus
22 Uqcrc2 67003
Co-fractionation Mus musculus
23 Pdk3  
Cross-Linking-MS (XL-MS) Mus musculus
24 Cox5a  
Co-fractionation Mus musculus
25 Sucla2  
Co-fractionation Mus musculus
26 Ndufs2  
Co-fractionation Mus musculus
27 Atp5k  
Co-fractionation Mus musculus
28 Atp5e  
Co-fractionation Mus musculus
29 Ndufs5  
Co-fractionation Mus musculus
30 Ndufs1  
Co-fractionation Mus musculus
31 Atp5j2  
Co-fractionation Mus musculus
32 Atp5a1 11946
Co-fractionation Mus musculus
33 Atp5l  
Co-fractionation Mus musculus
34 Ndufa5  
Co-fractionation Mus musculus
35 Fh1 14194
Co-fractionation Mus musculus
36 Sdha 66945
Co-fractionation Mus musculus
37 Ndufb7  
Co-fractionation Mus musculus
38 Ndufv3  
Co-fractionation Mus musculus
39 Suclg1  
Co-fractionation Mus musculus
40 Apoo  
Co-fractionation Mus musculus
41 Ndufa3  
Co-fractionation Mus musculus
42 Uqcr10  
Co-fractionation Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
43 Ndufv1  
Co-fractionation Mus musculus
44 Ndufa4  
Co-fractionation Mus musculus
45 Sdhb 67680
Co-fractionation Mus musculus
46 Ndufa10  
Co-fractionation Mus musculus
47 Mapt  
Affinity Capture-MS Mus musculus
48 Dld 13382
Co-fractionation Mus musculus
49 Ndufb6  
Co-fractionation Mus musculus
50 Idh3g  
Co-fractionation Mus musculus
51 Cyct  
Cross-Linking-MS (XL-MS) Mus musculus
52 Atp5c1  
Co-fractionation Mus musculus
53 Fancd2  
Affinity Capture-MS Mus musculus
54 Uqcrfs1 66694
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
55 Dlat  
Co-fractionation Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here